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Supraphysiologic glucocorticoid administration increased biomechanical bone strength of rats’ vertebral body

Laboratory Animal Research volume 31, pages 180–187 (2015)Cite this article

Abstract

The aim of this study is to assess the effects of different glucocorticoid administration protocols on biomechanical properties of the first lumbar vertebral body in rats. We divided 40 male rats into the following groups: control, dexamethasone (7 mg/week), dexamethasone (0.7 mg/week), methylprednisolone (7 mg/kg/week), methylprednisolone (5 mg/kg twice weekly), dexamethasone (7 mg/kg three times per week), dexamethasone (0.7 mg/kg three times per week, and low-level laser treated rats. Lumbar vertebrae in rats were exposed to the pulsed laser. We conducted a biomechanical test to examine the mechanical properties of vertebral body in rats’ lumbar bone. Supraphysiologic glucocorticoid administration protocols did not impair the biomechanical properties of rats’ vertebral bodies compared to control and laser-treated rats. Supraphysiologic glucocorticoid administration caused an anabolic effect on the vertebral bodies.

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Authors and Affiliations

  1. Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Azam Najar & Mohammad Bayat

  2. Department of Anatomy, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

    Mohammadjavad Fridoni

  3. Celluar and Molecular Biology Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Fatemesadat Rezaei & Mohammad Bayat

  4. School of Medicine, Arak University of Medical Sciences, Arak, Iran

    Saba Bayat

Authors
  1. Azam Najar
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  2. Mohammadjavad Fridoni
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  3. Fatemesadat Rezaei
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  4. Saba Bayat
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  5. Mohammad Bayat
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Corresponding author

Correspondence to Mohammad Bayat.

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Najar, A., Fridoni, M., Rezaei, F. et al. Supraphysiologic glucocorticoid administration increased biomechanical bone strength of rats’ vertebral body. Lab Anim Res 31, 180–187 (2015). https://doi.org/10.5625/lar.2015.31.4.180

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  • DOI: https://doi.org/10.5625/lar.2015.31.4.180

Keywords

  • Glucocorticoid administration
  • biomechanical properties
  • rat
  • cancellous bone
  • low-level laser therapy

Laboratory Animal Research

ISSN: 2233-7660