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Radiation-induced eosinophilic, polymorphic, and pruritic eruption in a pig skin model

Laboratory Animal Research volume 31, pages 204–208 (2015)Cite this article

Abstract

Eosinophilic, polymorphic and pruritic eruption associated with radiotherapy (EPPER) can occur in cancer patients after irradiation. In this study, we characterized the clinical and histopathological features of pig skin that developed widespread polymorphic and pruritic skin lesions following localized 50 Gy gammairradiation. The pigs developed pruritus 5–7 weeks after irradiation, and infiltration of the dermis by eosinophils was detected 4–7 weeks after irradiation. The irradiated animals also showed transiently increased numbers of peripheral eosinophils 5–7 weeks after treatment. Irradiation induced desquamation after 2–4 weeks, which and the desquamation gradually resolved after 7 weeks. These pathological changes correspond to those seen in irradiated human skin, indicating that this model could be useful for elucidating the pathogenesis of EPPER and for developing therapeutic and prophylactic methods.

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Authors and Affiliations

  1. Lab. of Radiation Exposure & Therapeutics, Korea Institute of Radiological & Medical Sciences (KIRAMS), 75 Nowonro, Nowon-gu, Seoul, 139-706, Korea

    Joong Sun Kim, Won Seok Jang, Sunhoo Park & Seung Sook Lee

  2. Research Center, Dongnam Institute of Radiological & Medical Sciences (DIRAMS), Busan, Korea

    Joong Sun Kim & Min Ji Bae

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  1. Joong Sun Kim
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  2. Won Seok Jang
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  3. Min Ji Bae
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  4. Sunhoo Park
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  5. Seung Sook Lee
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Correspondence to Joong Sun Kim or Seung Sook Lee.

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Kim, J.S., Jang, W.S., Bae, M.J. et al. Radiation-induced eosinophilic, polymorphic, and pruritic eruption in a pig skin model. Lab Anim Res 31, 204–208 (2015). https://doi.org/10.5625/lar.2015.31.4.204

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  • DOI: https://doi.org/10.5625/lar.2015.31.4.204

Keywords

Laboratory Animal Research

ISSN: 2233-7660