Skip to main content
Download PDF

Pathomorphological features of calcinosis circumscripta in a dog

Laboratory Animal Research volume 32, pages 74–77 (2016)Cite this article

Abstract

A 19-month-old male German shepherd dog was presented with a hindlimb footpad mass. The mass was excised and histopathology was performed. Grossly, the cut section of the mass had multiple wellcircumscribed nodules with a chalky appearance. Histopathologically, basophilic-stained calcium deposits of various sizes were distributed from dermis to subcutis, surrounded by epithelioid cells, multinucleated giant cells, and reactive fibroblasts. Myxoid metaplasia, calcium deposits in hair follicles, and psammomalike bodies were also found. These histopathologic observations will greatly help to understand the pathogenesis of calcinosis circumscripta.

References

  1. Tafti AK, Hanna P, Bourque AC. Calcinosis circumscripta in the dog: a retrospective pathological study. J Vet Med A Physiol Pathol Clin Med 2005; 52(1): 13–17.

    Article  CAS  Google Scholar 

  2. Ginel PJ, López R, Rivas R, Pérez J, Mozos E. A further case of medroxyprogesterone acetate associated with calcinosis circumscripta in the dog. Vet Rec 1995; 136(2): 44–45.

    Article  CAS  Google Scholar 

  3. Smack D, Norton SA, Fitzpatrick JE. Proposal for a pathogenesisbased classification of tumoral calcinosis. Int J Dermatol 1996; 35(4): 265–271.

    Article  CAS  Google Scholar 

  4. Das DK. Psammoma body: a product of dystrophic calcification or of a biologically active process that aims at limiting the growth and spread of tumor. Diagn Cytopathol 2009; 37(7): 534–541.

    Article  Google Scholar 

  5. Belliveau MJ, Liao WN, Brownstein S, Manusow JS, Jordan DR, Gilberg S, Mintsioulis G. Myxomatous corneal degeneration: a clinicopathological study of six cases and a review of the literature. Surv Ophthalmol 2012; 57(3): 264–271.

    Article  Google Scholar 

  6. Kwon GH, Rha SE, Ki EY, Bae SN, Lee A. Imaging findings of fallopian tube leiomyoma with myxoid degeneration: a case report. Clin Imaging 2015; 39(6): 1119–1122.

    Article  Google Scholar 

  7. Roosens B, Bala G, Droogmans S, Van Camp G, Breyne J, Cosyns B. Animal models of organic heart valve disease. Int J Cardiol 2013; 165(3): 398–409.

    Article  Google Scholar 

  8. Scranton PE Jr, Farrar EL. Mucoid degeneration of the patellar ligament in athletes. J Bone Joint Surg Am 1992; 74(3): 435–437.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, College of Veterinary Medicine, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, Korea

    Eun-Mi Lee, Ah-Young Kim, Eun-Joo Lee & Kyu-Shik Jeong

  2. Stem Cell Therapeutic Research Institute, Kyungpook National University, Daegu, Korea

    Eun-Mi Lee, Ah-Young Kim, Eun-Joo Lee & Kyu-Shik Jeong

Authors
  1. Eun-Mi Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ah-Young Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Eun-Joo Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kyu-Shik Jeong
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kyu-Shik Jeong.

Rights and permissions

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lee, EM., Kim, AY., Lee, EJ. et al. Pathomorphological features of calcinosis circumscripta in a dog. Lab Anim Res 32, 74–77 (2016). https://doi.org/10.5625/lar.2016.32.1.74

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.5625/lar.2016.32.1.74

Keywords

Laboratory Animal Research

ISSN: 2233-7660