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Cardiopulmonary effects of thiopental versus propofol as an induction agent prior to isoflurane anesthesia in chair trained rhesus macaques (Macaca mulatta)

Laboratory Animal Research volume 32, pages 8–15 (2016)Cite this article

Abstract

The purpose of this study was to evaluate the effects of thiopental versus propofol on cardiopulmonary functions, when used as an induction agent prior to isoflurane anesthesia in rhesus monkeys. Eight healthy rhesus monkeys weighing 3.72 to 5.7 kg, 4-5 years old, were used in the study. Anesthesia was induced with thiopental or propofol intravenous injection, and then maintained with isoflurane in oxygen for 45 minutes. Cardiopulmonary measurements were obtained before and 5, 15, 30, 45, and 60 minutes after induction. The induction doses of thiopental and propofol were 19.41±0.54 and 9.33±1.02 mg/kg, respectively. In both groups, the values of heart rate, respiratory rate, temperature, systolic blood pressure, mean blood pressure, diastolic blood pressure, pH, and lactate were decreased, while the values of partial pressure of carbon dioxide, partial pressure of oxygen, total carbon dioxide, bicarbonate, oxygen saturation, and base excess in the extracellular fluid were increased, as compared with baseline. Systolic blood pressure was significantly lower in thiopental group compare to propofol group. Induction time was very short in both agents but not revealed a significant difference between both groups. However, recovery time was extremely faster in the propofol group. Our results demonstrated that propofol provides a minor suppression in systolic arterial blood pressure than thiopental sodium. In addition, propofol have a fast recovery effect from the anesthesia as well. Furthermore, it is suggested that thiopental sodium could also be used to induce anesthesia instead of propofol, despite slight more suppression of cardiopulmonary function compared to thiopental sodium.

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Authors and Affiliations

  1. Transplantation Research Institute, Medical Research Center, Department of Medicine, Seoul National University College of Medicine, Seoul, Korea

    Yun-Jung Choi, Hye-Jin Park, Hyeon-Ho Kim, Yun-Jin Lee, Kyeong-Cheon Jung, Seong-Hoe Park & Jae-Il Lee

  2. Department of Medicine, Seoul National University College of Medicine, Seoul, Korea

    Yun-Jung Choi, Seong-Hoe Park & Jae-Il Lee

  3. Department of Pathology, Seoul National University College of Medicine, Seoul, Korea

    Kyeong-Cheon Jung

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  1. Yun-Jung Choi
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  2. Hye-Jin Park
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  3. Hyeon-Ho Kim
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Correspondence to Jae-Il Lee.

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Choi, YJ., Park, HJ., Kim, HH. et al. Cardiopulmonary effects of thiopental versus propofol as an induction agent prior to isoflurane anesthesia in chair trained rhesus macaques (Macaca mulatta). Lab Anim Res 32, 8–15 (2016). https://doi.org/10.5625/lar.2016.32.1.8

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  • DOI: https://doi.org/10.5625/lar.2016.32.1.8

Keywords

Laboratory Animal Research

ISSN: 2233-7660