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Reference values of clinical pathology parameters in cynomolgus monkeys (Macaca fascicularis) used in preclinical studies

Laboratory Animal Research volume 32, pages 79–86 (2016)Cite this article

Abstract

Nonhuman primates are increasingly used in biomedical research since they are highly homologous to humans compared to other rodent animals. However, there is limited reliable reference data of the clinical pathology parameters in cynomolgus monkeys, and in particular, only some coagulation and urinalysis parameters have been reported. Here, we reported the reference data of clinical chemical, hematological, blood coagulation, and urinalysis parameters in cynomolgus monkeys. The role of sex differences was analyzed and several parameters (including hematocrit, hemoglobin, red blood cell, blood urea nitrogen, total bilirubin, alkaline phosphatase, creatinine kinase, gamma-glutamyl tranferase, and lactate dehydrogenase) significantly differed between male and female subjects. In addition, compared to previous study results, lactate dehydrogenase, creatinine kinase, and aspartate aminotransferase showed significant variation. Interstudy differences could be affected by several factors, including age, sex, geographic origin, presence/absence of anesthetics, fasting state, and the analytical methods used. Therefore, it is important to deliberate with the overall reference indices. In conclusion, the current study provides a comprehensive and updated reference data of the clinical pathology parameters in cynomolgus monkeys and provides improved assessment criteria for evaluating preclinical studies or biomedical research.

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Authors and Affiliations

  1. Pathology Research Center, Korea Institute of Toxicology (KIT), 141 Gajeongro, Yuseong-Gu, Daejeon, 305-343, Korea

    Hyun-Kyu Park, Jae-Woo Cho, Byoung-Seok Lee, Heejin Park, Ji-Seok Han, Wan-Jung Im, Do-Yong Park, Woo-Jin Kim & Yong-Bum Kim

  2. Pathology Research Center, Korea Institute of Toxicology (KIT), 30 Baekhak 1-gil, Jeongeup, Jeonbuk, Korea

    Mi-Jin Yang

  3. General Toxicology Research Center, Korea Institute of Toxicology (KIT), 30 Baekhak 1-gil, Jeongeup, Jeonbuk, Korea

    Su-Cheol Han

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  1. Hyun-Kyu Park
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  2. Jae-Woo Cho
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  3. Byoung-Seok Lee
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  4. Heejin Park
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  11. Yong-Bum Kim
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Correspondence to Yong-Bum Kim.

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Park, HK., Cho, JW., Lee, BS. et al. Reference values of clinical pathology parameters in cynomolgus monkeys (Macaca fascicularis) used in preclinical studies. Lab Anim Res 32, 79–86 (2016). https://doi.org/10.5625/lar.2016.32.2.79

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  • DOI: https://doi.org/10.5625/lar.2016.32.2.79

Keywords

  • Cynomolgus monkey
  • clinical chemistry
  • hematology
  • blood coagulation
  • urinalysis

Laboratory Animal Research

ISSN: 2233-7660