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Clinical and magnetic resonance imaging features of compressive cervical myelopathy with traumatic intervertebral disc herniation in cynomolgus macaque (Macaca fascicularis)

Laboratory Animal Research volume 32, pages 267–271 (2016)Cite this article

Abstract

Intervertebral disc herniation (IVDH) with nucleus pulposus extrusion, traumatic or not, is a devastating clinical condition accompanied by neurological problems. Here we report a cynomolgus macaque suffering from acute and progressive neurological dysfunction by a blunt trauma due to neck collar, an animal handling device. Tetraplegia, urinary incontinence, decreased proprioception, and imperception of pain were shown on physical and neurological examinations. MRI sagittal T2 weighted sequences revealed an extensive protrusion of disc material between C2 and C3 cervical vertebra, and this protrusion resulted in central stenosis of the spinal cord. Histopathologic findings showed a large number of inflammatory cells infiltrated at sites of spinal cord injury (SCI). This case is the first report of compressive cervical SCI caused by IVDH associated with blunt trauma.

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Authors and Affiliations

  1. Transplantation Research Institute, Medical Research Center, Department of Medicine, Seoul National University College of Medicine, 103 Daehakro, Jongno-gu, Seoul, 110-799, Korea

    Yun-Jung Choi, Hye-Jin Park, Kyeong Cheon Jung, Seong Hoe Park & Jae-Il Lee

  2. Department of Medicine, Seoul National University College of Medicine, Seoul, Korea

    Yun-Jung Choi, Seong Hoe Park & Jae-Il Lee

  3. Department of Pathology, Seoul National University College of Medicine, Seoul, Korea

    Kyeong Cheon Jung

  4. Department of Radiology, Seoul National University Hospital, Seoul, Korea

    Chul-Ho Sohn

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  1. Yun-Jung Choi
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Correspondence to Jae-Il Lee.

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Choi, YJ., Park, HJ., Sohn, CH. et al. Clinical and magnetic resonance imaging features of compressive cervical myelopathy with traumatic intervertebral disc herniation in cynomolgus macaque (Macaca fascicularis). Lab Anim Res 32, 267–271 (2016). https://doi.org/10.5625/lar.2016.32.4.267

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  • DOI: https://doi.org/10.5625/lar.2016.32.4.267

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Laboratory Animal Research

ISSN: 2233-7660