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Effects of coenzyme Q10 on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity

Laboratory Animal Research volume 33, pages 24–31 (2017)Cite this article

Abstract

The study was performed to see the effects of coenzyme Q10 (CoQ10) on blood biochemical components and hepatic antioxidant system in rats exposed to lipopolysaccharide (LPS)-induced toxicity. A total of 24 rats were allocated to four groups: control (CON), 100 mg/kg BW of LPS (LPS), 100 mg of CoQ10/kg BW with LPS (LCQI) and 300 mg of CoQ10/kg BW with LPS (LCQII). The LPS and LCQI groups showed a significant (P<0.05) increase in the relative spleen weight compared with the CON group without affecting body and liver weights. The blood alanine aminotransferase (ALT) level in the LPS group was significantly (P<0.05) greater than that in the CON group, while supplementation with 100 or 300 mg CoQ10 to rats injected with LPS normalized the ALT level in the CON group. In antioxidant systems, the LPS group showed a significantly (P<0.05) higher mRNA and activity of superoxide dismutase (SOD) than the CON group. The supplementation with CoQ10 to the LPS-treated group normalized the level of SOD, which was comparable to the level of the CON group. Both the mRNA expression and activity of glutathione peroxidase in the LCQI and LCQII groups were higher (P<0.05) than that of the LPS group. However, administration of LPS or CoQ10 unaffected the level of catalase and total antioxidant power. The level of lipid peroxidation in the LCQII group was lower (P<0.05) than that in the LPS group. In conclusion, CoQ10 exerted its favorable effect against liver damage by modulation of antioxidant enzymes in LPS treated rats.

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Acknowledgments

This research was supported by agrant from Gyeongnam National University of Science and Technology in 2016. The authors also thank the Regional Animal Research Center at GNTECH to use the analysis instruments.

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Authors and Affiliations

  1. Department of Animal Science and Biotechnology, and the Regional Animal Research Center, Gyeongnam National University of Science and Technology, Chilam-Dong 150, Jinju, Gyeongnam, 52725, Korea

    Min-Hae Song, Ha-Na Kim & In-Surk Jang

  2. Department of Clinical Laboratory Science, Dong-Eui Univerisity, Busan, Korea

    Yong Lim

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  1. Min-Hae Song
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Correspondence to In-Surk Jang.

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Song, MH., Kim, HN., Lim, Y. et al. Effects of coenzyme Q10 on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity. Lab Anim Res 33, 24–31 (2017). https://doi.org/10.5625/lar.2017.33.1.24

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  • DOI: https://doi.org/10.5625/lar.2017.33.1.24

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Laboratory Animal Research

ISSN: 2233-7660