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Annual tendency of research papers used ICR mice as experimental animals in biomedical research fields

Laboratory Animal Research volume 33, pages 171–174 (2017)Cite this article

Abstract

Institute of Cancer Research (ICR) mice have been widely used in various research fields including toxicology, oncology, pharmacology, and pharmaceutical product safety testing for decades. However, annual tendency of research papers involving ICR mice in various biomedical fields has not been previously analyzed. In this study, we examined the numbers of papers that used ICR mice as experimental animals in the social science, natural science, engineering, medicine-pharmacy, marine agriculture-fishery, and art-kinesiology fields by analyzing big data. Numbers of ICR mouse-used papers gradually increased from 1961 to 2014, but small decreases were observed in 2015 and 2016. The largest number of ICR-used papers were published in the medicine-pharmacy field, followed by natural science and art-kinesiology fields. There were no ICR mouse-used papers in other fields. Furthermore, ICR mice have been widely employed in cell biology studies within the natural science field as well as in biochemistry and pathology in the medicine-pharmacy field. Few ICR mouse-used papers were published in exercise biochemistry and exercise nutrition in the art-kinesiology field. Regardless in most fields, the total numbers of published papers involving ICR mice were higher in 2014 than in other years, although the numbers in some fields including dentistry, veterinary science, and dermatology were high in 2016. Taken together, the present study shows that various ICR stocks, including Korl:ICR mice, are widely employed as experimental animals in various biomedical research fields.

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Acknowledgments

This project was supported by a 2015 grant from BIOREIN (Laboratory Animal Bio Resources Initiative) of the Korean Ministry of Food and Drug Safety.

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Authors and Affiliations

  1. Department of Biomaterials Science, College of Natural Resources & Life Science/Life and Industry Convergence Research Institute, Pusan National University, 50 Cheonghakri, Samnangjin-eup, Miryang, Gyeongnam, 50463, Korea

    Ji Eun Kim & Dae Youn Hwang

  2. Department of Sports Health Care Science, Sang Myung University, Seoul, Korea

    Jung Hoon Nam

  3. Department of Health and Exercise Science, Korea National Sport University, Seoul, Korea

    Joon Young Cho

  4. College of Veterinary Medicine, Kyungpook National University, Daegu, Korea

    Kil Soo Kim

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  1. Ji Eun Kim
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  2. Jung Hoon Nam
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Correspondence to Dae Youn Hwang.

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Kim, J.E., Nam, J.H., Cho, J.Y. et al. Annual tendency of research papers used ICR mice as experimental animals in biomedical research fields. Lab Anim Res 33, 171–174 (2017). https://doi.org/10.5625/lar.2017.33.2.171

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  • DOI: https://doi.org/10.5625/lar.2017.33.2.171

Keywords

Laboratory Animal Research

ISSN: 2233-7660