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Safety of 8-weeks oral administration of Arctium lappa L.

Laboratory Animal Research volume 33, pages 251–255 (2017)Cite this article

Abstract

Recently, worldwide dietary reference intakes have been considered an important guideline for public health. Some governments and the World Health Organization (WHO) provide guidelines concerning dietary intake. Although an ingredient may have a history of use as a culinary material, changes in the environment over time suggest that the acceptable maximum intake each of food/culinary material should be regularly evaluated. Arctium lappa L. has been used as a culinary material for many centuries in Korea and Japan and some recent studies have reported related therapeutic effects. However, there are no reports on the safety of repeated oral administration. In this study, we evaluated the safety of a 8-weeks repeated oral intake of A. lappa. We concluded that treatment with <250 mg/kg A. lappa, which was within the safety range, resulted in body weight decrease and blood glucose suppression.

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Author notes

  1. These authors contributed equally to this work.

Authors and Affiliations

  1. College of Oriental Medicine, Dongshin University, Naju, Jeonnam, 58245, Korea

    So-Hyeon Bok, Dae-Hun Park & Kyung-Mok Park

  2. Department of Pharmacy, College of Pharmacy, Mokpo National University, Muan, Korea

    Seung Sik Cho

  3. College of Veterinary Medicine, Chonnam National University, Gwangju, Korea

    Chun-Sik Bae

Authors
  1. So-Hyeon Bok
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  2. Seung Sik Cho
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  3. Chun-Sik Bae
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  4. Dae-Hun Park
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  5. Kyung-Mok Park
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Corresponding authors

Correspondence to Dae-Hun Park or Kyung-Mok Park.

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://doi.org/creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bok, SH., Cho, S.S., Bae, CS. et al. Safety of 8-weeks oral administration of Arctium lappa L.. Lab Anim Res 33, 251–255 (2017). https://doi.org/10.5625/lar.2017.33.3.251

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  • DOI: https://doi.org/10.5625/lar.2017.33.3.251

Keywords

  • Arctium lappa L.
  • safety of repeated oral intake (administration)
  • body weight decrement
  • blood glucose suppression

Laboratory Animal Research

ISSN: 2233-7660