Skip to main content

Safety of 8-weeks oral administration of Arctium lappa L.

Abstract

Recently, worldwide dietary reference intakes have been considered an important guideline for public health. Some governments and the World Health Organization (WHO) provide guidelines concerning dietary intake. Although an ingredient may have a history of use as a culinary material, changes in the environment over time suggest that the acceptable maximum intake each of food/culinary material should be regularly evaluated. Arctium lappa L. has been used as a culinary material for many centuries in Korea and Japan and some recent studies have reported related therapeutic effects. However, there are no reports on the safety of repeated oral administration. In this study, we evaluated the safety of a 8-weeks repeated oral intake of A. lappa. We concluded that treatment with <250 mg/kg A. lappa, which was within the safety range, resulted in body weight decrease and blood glucose suppression.

References

  1. Ministry of Health and Welfare in Korea, 2010 Dietary reference intakes in Korean, 2013.

    Google Scholar 

  2. WHO, Food and Agriculture Organization of the United Nations. Carbohydrates in human nutrition. Report of a Joint FAO/WHO Expert Consultation. FAO Food Nutr Pap 1998; 66: 1–140.

    Google Scholar 

  3. WHO, Sugars intake for adults and children, 2015.

    Google Scholar 

  4. WHO, Food and Agriculture Organization of the United Nations, United Nations University, Protein and amino acid requirements in human nutrition, Report of a joint FAO/WHO/UNU expert consultation (WHO Technical Report Series 935.), 2007.

    Google Scholar 

  5. Li A, Zhang X, Shu M, Wu M, Wang J, Zhang J, Wang R, Li P, Wang Y. Arctigenin suppresses renal interstitial fibrosis in a rat model of obstructive nephropathy. Phytomedicine 2017; 30: 28–41.

    Article  CAS  Google Scholar 

  6. Huang J, Xiao L, Wei JX, Shu YH, Fang SQ, Wang YT, Lu XM. Protective effect of arctigenin on ethanol-induced neurotoxicity in PC12 cells. Mol Med Rep 2017; 15(4): 2235–2240.

    Article  CAS  Google Scholar 

  7. Li XM, Miao Y, Su QY, Yao JC, Li HH, Zhang GM. Gastroprotective effects of arctigenin of Arctium lappa L. on a rat model of gastric ulcers. Biomed Rep 2016; 5(5): 589–594.

    Article  CAS  Google Scholar 

  8. Lou C, Zhu Z, Zhao Y, Zhu R, Zhao H. Arctigenin, a lignan from Arctium lappa L., inhibits metastasis of human breast cancer cells through the downregulation of MMP-2/-9 and heparanase in MDA-MB-231 cells. Oncol Rep 2017; 37(1): 179–184.

    Article  Google Scholar 

  9. Suksomboon N, Poolsup N, Punthanitisarn S. Effect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis. J Clin Pharm Ther 2016; 41(2): 180–188.

    Article  CAS  Google Scholar 

  10. de Mello VD, Lankinen MA, Lindström J, Puupponen-Pimiä R, Laaksonen DE, Pihlajamäki J, Lehtonen M, Uusitupa M, Tuomilehto J, Kolehmainen M, Törrönen R, Hanhineva K. Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes. Mol Nutr Food Res 2017; 61(9).

    Google Scholar 

  11. Khosrozadeh M, Heydari N, Abootalebi M. The Effect of Abelmoschus Esculentus on Blood Levels of Glucose in Diabetes Mellitus. Iran J Med Sci 2016; 41(3 Suppl): S63.

    PubMed  PubMed Central  Google Scholar 

  12. Costello RB, Dwyer JT, Saldanha L, Bailey RL, Merkel J, Wambogo E. Do Cinnamon Supplements Have a Role in Glycemic Control in Type 2 Diabetes? A Narrative Review. J Acad Nutr Diet 2016; 116(11): 1794–1802.

    Article  Google Scholar 

  13. Shin HK, Lee YM, ‘Fake Bitsuo Oh’ surge… Cosumers “10% only real”, Yonhap News, April 22, 2015.

    Google Scholar 

  14. Han J, Luan DH. Sow abortion caused by feeding Cynanchum auriculatum. Animal Husb. Vet. Med. Xumu yu Shouyi 1984; 16(6): 266.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Dae-Hun Park or Kyung-Mok Park.

Rights and permissions

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://doi.org/creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bok, SH., Cho, S.S., Bae, CS. et al. Safety of 8-weeks oral administration of Arctium lappa L.. Lab Anim Res 33, 251–255 (2017). https://doi.org/10.5625/lar.2017.33.3.251

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.5625/lar.2017.33.3.251

Keywords