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Dendropanax morbifera Léveille extract ameliorates d-galactose-induced memory deficits by decreasing inflammatory responses in the hippocampus

Laboratory Animal Research volume 33, pages 283–290 (2017)Cite this article

Abstract

In the present study, we examined the effects of Dendropanax morbifera Léveille leaf extract (DML) on dgalactose-induced morphological changes in microglia and cytokines, including pro-inflammatory cytokines (interleukin [IL]-1β, IL-6, and tumor necrosis factor [TNF]-α) and anti-inflammatory cytokines (IL-4 and IL-10) in the hippocampus. Administration of DML to d-galactose-treated mice significantly improved d-galactose-induced reduction in escape latency, swimming speed, and spatial preference for the target quadrant. In addition, administration of DML to d-galactose-treated mice significantly ameliorated the microglial activation and increases of IL-1β, IL-6, and TNF-α levels in the hippocampus. Administration of d-galactose significantly reduced IL-4 levels in the hippocampus, while administration of DML to d-galactose-treated mice significantly increased IL-4 level. However, we did not observe any significant changes in IL-10 levels in hippocampal homogenates. These results suggest that DML reduces d-galactose-induced mouse senescence by reducing pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α, as well as increasing anti-inflammatory cytokine IL-4.

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Authors and Affiliations

  1. Department of Anatomy, College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, 24341, South Korea

    Kwon Young Lee &  Jung Hoon Choi DVM, PhD

  2. Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, South Korea

    Hyo Young Jung, Dae Young Yoo, Woosuk Kim, Jong Whi Kim, Yeo Sung Yoon & In Koo Hwang

  3. Department of Biochemistry and Molecular Biology, Research Institute of Oral Sciences, College of Dentistry, Gangneung-Wonju National University, Gangneung, 25457, South Korea

    Hyun Jung Kwon & Dae Won Kim

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  1. Kwon Young Lee
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Correspondence to Jung Hoon Choi DVM, PhD.

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Lee, K.Y., Jung, H.Y., Yoo, D.Y. et al. Dendropanax morbifera Léveille extract ameliorates d-galactose-induced memory deficits by decreasing inflammatory responses in the hippocampus. Lab Anim Res 33, 283–290 (2017). https://doi.org/10.5625/lar.2017.33.4.283

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  • DOI: https://doi.org/10.5625/lar.2017.33.4.283

Keywords

  • Dendropanax morbifera extract
  • d-galactose
  • hippocampus
  • inflammation
  • memory

Laboratory Animal Research

ISSN: 2233-7660