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Dendropanax morbifera Léveille extract ameliorates d-galactose-induced memory deficits by decreasing inflammatory responses in the hippocampus
Laboratory Animal Research volume 33, pages283–290(2017)
In the present study, we examined the effects of Dendropanax morbifera Léveille leaf extract (DML) on dgalactose-induced morphological changes in microglia and cytokines, including pro-inflammatory cytokines (interleukin [IL]-1β, IL-6, and tumor necrosis factor [TNF]-α) and anti-inflammatory cytokines (IL-4 and IL-10) in the hippocampus. Administration of DML to d-galactose-treated mice significantly improved d-galactose-induced reduction in escape latency, swimming speed, and spatial preference for the target quadrant. In addition, administration of DML to d-galactose-treated mice significantly ameliorated the microglial activation and increases of IL-1β, IL-6, and TNF-α levels in the hippocampus. Administration of d-galactose significantly reduced IL-4 levels in the hippocampus, while administration of DML to d-galactose-treated mice significantly increased IL-4 level. However, we did not observe any significant changes in IL-10 levels in hippocampal homogenates. These results suggest that DML reduces d-galactose-induced mouse senescence by reducing pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α, as well as increasing anti-inflammatory cytokine IL-4.
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Lee, K.Y., Jung, H.Y., Yoo, D.Y. et al. Dendropanax morbifera Léveille extract ameliorates d-galactose-induced memory deficits by decreasing inflammatory responses in the hippocampus. Lab Anim Res 33, 283–290 (2017). https://doi.org/10.5625/lar.2017.33.4.283
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