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Protective effects of cultured and fermented ginseng extracts against scopolamine-induced memory loss in a mouse model

Abstract

This study was performed to investigate the effect of a concentrate of fermented wild ginseng root culture (HLJC0701) on memory improvement in the scopolamine (SPL)-induced memory-deficient mouse model. Eight-week-old male ICR mice were used to evaluate the protective effect of HLJC0701 against the SPL-induced memory loss animal model. The Morris water maze test, which measures hippocampus-dependent learning ability, and the Y-maze test, a short-term memory assessment test, were performed and related markers were analyzed. HLJG0701-treated groups displayed significantly reduced acetylcholinesterase activity and increased acetylcholine level compared with the SPL-administered group (SPL-G) (P<0.05). In the Y-maze test, the spontaneous alternation in al HLJC0711-treated groups was significantly increased compared with that in SPL-G (P<0.05). In the Morris water maze test, the escape latency and time spent in the target quadrant in all HLJC0701-treated groups were significantly decreased and increased, respectively, compared with those in SPL-G (P<0.05). In addition, the brain-derived neurotrophic factor level in groups treated with HLJC0701 300 and 600 mg/kg body weight was significantly increased compared with that in SPL-G (P<0.05). These results suggest that the HLJC0701 may protect against memory loss by inhibiting acetylcholinesterase activity and preventing acetylcholine deficiency.

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Correspondence to Hu-Jang Lee.

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://doi.org/creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Han, S., Kim, S., Yun, Y.W. et al. Protective effects of cultured and fermented ginseng extracts against scopolamine-induced memory loss in a mouse model. Lab Anim Res 34, 37–43 (2018). https://doi.org/10.5625/lar.2018.34.1.37

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Keywords

  • Memory loss
  • ginsenosides
  • scopolamine
  • acetylcholine
  • mice