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Protective effects of cultured and fermented ginseng extracts against scopolamine-induced memory loss in a mouse model

Laboratory Animal Research volume 34, pages 37–43 (2018)Cite this article

Abstract

This study was performed to investigate the effect of a concentrate of fermented wild ginseng root culture (HLJC0701) on memory improvement in the scopolamine (SPL)-induced memory-deficient mouse model. Eight-week-old male ICR mice were used to evaluate the protective effect of HLJC0701 against the SPL-induced memory loss animal model. The Morris water maze test, which measures hippocampus-dependent learning ability, and the Y-maze test, a short-term memory assessment test, were performed and related markers were analyzed. HLJG0701-treated groups displayed significantly reduced acetylcholinesterase activity and increased acetylcholine level compared with the SPL-administered group (SPL-G) (P<0.05). In the Y-maze test, the spontaneous alternation in al HLJC0711-treated groups was significantly increased compared with that in SPL-G (P<0.05). In the Morris water maze test, the escape latency and time spent in the target quadrant in all HLJC0701-treated groups were significantly decreased and increased, respectively, compared with those in SPL-G (P<0.05). In addition, the brain-derived neurotrophic factor level in groups treated with HLJC0701 300 and 600 mg/kg body weight was significantly increased compared with that in SPL-G (P<0.05). These results suggest that the HLJC0701 may protect against memory loss by inhibiting acetylcholinesterase activity and preventing acetylcholine deficiency.

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Authors and Affiliations

  1. College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, 1 Chungdae-ro, Seowon-Gu, Cheongju, Chungbuk, 28644, Korea

    Song-Hee Han, Sung-June Kim, Young Won Yun, Sang Yoon Nam & Beom-Jun Lee

  2. College of Veterinary Medicine and Institute of Animal Medicine, Gyeongsang National University, 501 Jinju-daero, Jinju, 52828, Korea

    Hu-Jang Lee

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  1. Song-Hee Han
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Correspondence to Hu-Jang Lee.

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Han, SH., Kim, SJ., Yun, Y.W. et al. Protective effects of cultured and fermented ginseng extracts against scopolamine-induced memory loss in a mouse model. Lab Anim Res 34, 37–43 (2018). https://doi.org/10.5625/lar.2018.34.1.37

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  • DOI: https://doi.org/10.5625/lar.2018.34.1.37

Keywords

Laboratory Animal Research

ISSN: 2233-7660