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RETRACTED ARTICLE: Effects of DA-5513 on alcohol metabolism and alcoholic fatty liver in rats

Laboratory Animal Research volume 34, pages 49–57 (2018)Cite this article

This article was retracted on 11 June 2020

This article has been updated

Abstract

Hangover is characterized by a number of unpleasant physical and mental symptoms that occur after heavy alcohol drinking. In addition, consistently excessive alcohol intake is considered as a major reason causes liver disease. The present study investigated the in vivo effects of DA-5513 (Morning careê Kang Hwang) on biological parameters relevant to hangover relief and alcoholic fatty liver. Blood alcohol and acetaldehyde concentrations were determined in rats administered a single dose of alcohol and treated with DA-5513 or commercially available hangover relief beverages (Yeomyungê and Ukonê). The effects of DA-5513 on alcoholic fatty liver were also determined in rats fed alcohol-containing Lieber-DeCarli diets for 4 weeks. Serum liver function markers (aspartate and alanine aminotransferase activities) and serum/liver lipid levels were assessed. Blood alcohol and acetaldehyde concentrations were lower in the groups treated with DA-5513 or Yeomyungê, as compared with control rats. However, Ukonê did not produce any significant effects on these parameters. Treatment with DA-5513 significantly reduced serum aspartate and alanine aminotransferase activities and markedly reduced serum cholesterol and triglyceride levels, as compared with control rats. Histological observations using Oil Red O staining found that DA-5513 delayed the development of alcoholic fatty liver by reversing hepatic fat accumulation. These findings suggest that DA-5513 could have a beneficial effect on alcohol-induced hangovers and has the potential to ameliorate alcoholic fatty liver.

Change history

  • 11 June 2020

    An amendment to this paper has been published and can be accessed via the original article.

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Author notes

  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Formulation Development, Dong-A Pharmaceutical Co. Ltd., Yongin, Korea

    Jae Young Yu, Hyoung Geun Park & Joon Ho Jun

  2. College of Pharmacy, Yeungnam University, 214-1, Dae-dong, Gyeongsan, 712-749, Korea

    Hanh Thuy Nguyen, Chul Soon Yong & Jong Oh Kim

  3. National Institute of Pharmaceutical Technology, Hanoi University of Pharmacy, Hanoi, Vietnam

    Hanh Thuy Nguyen

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  1. Jae Young Yu
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  2. Hanh Thuy Nguyen
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  3. Chul Soon Yong
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  4. Hyoung Geun Park
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Corresponding author

Correspondence to Jong Oh Kim.

Additional information

This article has been retracted at the request of authors. It has come to our attention that Seoul National University co-own the data presented in the current study with Dong-A Pharma. Unfortunately, we did not obtain permission to publish the data prior to publication and did not give proper credit to all collaborators on this research project. In addition, authors have been unable to replicate the results presented after conducting further experiments using DA-5513. We are therefore concerned about the reliability of the findings. All authors agreed to this retraction.

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Yu, J.Y., Nguyen, H.T., Yong, C.S. et al. RETRACTED ARTICLE: Effects of DA-5513 on alcohol metabolism and alcoholic fatty liver in rats. Lab Anim Res 34, 49–57 (2018). https://doi.org/10.5625/lar.2018.34.2.49

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  • DOI: https://doi.org/10.5625/lar.2018.34.2.49

Keywords

  • Morning careê
  • hangover
  • acetaldehyde
  • alcohol-induced fatty liver
  • hepatic triglyceride

Laboratory Animal Research

ISSN: 2233-7660