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Mouse models of breast cancer in preclinical research

Laboratory Animal Research volume 34, pages 160–165 (2018)Cite this article

Abstract

Breast cancer remains the second leading cause of cancer death among woman, worldwide, despite advances in identifying novel targeted therapies and the development of treating strategies. Classification of clinical subtypes (ER+, PR+, HER2+, and TNBC (Triple-negative)) increases the complexity of breast cancers, which thus necessitates further investigation. Mouse models used in breast cancer research provide an essential approach to examine the mechanisms and genetic pathway in cancer progression and metastasis and to develop and evaluate clinical therapeutics. In this review, we summarize tumor transplantation models and genetically engineered mouse models (GEMMs) of breast cancer and their applications in the field of human breast cancer research and anti-cancer drug development. These models may help to improve the knowledge of underlying mechanisms and genetic pathways, as well as creating approaches for modeling clinical tumor subtypes, and developing innovative cancer therapy.

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Authors and Affiliations

  1. Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Gyeonggi, Korea

    Mi Kyung Park & Ho Lee

  2. College of Pharmacy, Dongguk University, Gyeonggi, Korea

    Chang Hoon Lee

  3. Carcinogenesis and Metastasis Research Branch, National Cancer Center, Gyeonggi, Korea

    Ho Lee

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  1. Mi Kyung Park
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Correspondence to Ho Lee.

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Park, M.K., Lee, C.H. & Lee, H. Mouse models of breast cancer in preclinical research. Lab Anim Res 34, 160–165 (2018). https://doi.org/10.5625/lar.2018.34.4.160

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Laboratory Animal Research

ISSN: 2233-7660