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In vitro and in vivo inhibition of Helicobacter pylori by Lactobacilllus paracasei HP7

Laboratory Animal Research volume 34, pages 216–222 (2018)Cite this article

Abstract

The efficacy of standard therapeutic strategies for Helicobacter pylori (H. pylori) infection is decreasing over time due to the emergence of drug-resistant strains. As an alternative, the present study investigated the capacity of Lactobacilllus paracasei (L. paracasei) HP7, isolated from kimchi, to inhibit H. pylori growth. The effects of L. paracasei HP7 on H. pylori adhesion and H. pylori-induced inflammation were examined in ACS human gastric adenocarcinoma epithelial cells and a mouse model of H. pylori SS1 infection. L. paracasei HP7 reduced H. pylori adhesion to ACS cells and suppressed the inflammatory response in infected cells by downregulating interleukin-8. H. pylori colonization in the stomach of C57BL/6 mice was demonstrated by rapid urease test, and results showed significant decrease in mice post-treated with L. paracasei HP7. Additionally, L. paracasei HP7 decreased gastric inflammation and epithelial lesions in the stomach of H. pylori-infected mice. These results demonstrate that L. paracasei HP7 treatment can inhibit H. pylori growth and is thus a promising treatment for patients with gastric symptoms such as gastritis that are caused by H. pylori infection.

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Authors and Affiliations

  1. Division of Gastroenterology, Vievisnamuh Hospital, Seoul, Korea

    Seong-Soo Hong

  2. Center for Animal Resource Development, Wonkwang University, 460 Iksandaero, Iksan, Jeonbuk, 54538, Korea

    Hyun-A Lee & Okjin Kim

  3. R & BD Center, Korea Yakult Co., Ltd., Yongin, Korea

    Joo Yun Kim, Ji-Woong Jeong, Jae-Jung Shim, Jung Lyoul Lee & Jae-Hun Sim

  4. Department of Companion Animal and Animal Resources Science, Joongbu University, Geumsan-gun, Korea

    Yungho Chung

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  1. Seong-Soo Hong
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Correspondence to Okjin Kim.

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Hong, SS., Lee, HA., Kim, J.Y. et al. In vitro and in vivo inhibition of Helicobacter pylori by Lactobacilllus paracasei HP7. Lab Anim Res 34, 216–222 (2018). https://doi.org/10.5625/lar.2018.34.4.216

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  • DOI: https://doi.org/10.5625/lar.2018.34.4.216

Keywords

  • Lactobacilllus paracasei
  • HP7
  • Helicobacter pylori
  • ACS cells
  • Kimchi

Laboratory Animal Research

ISSN: 2233-7660