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Genetic and morphometric characteristics of Korean wild mice (KWM/Hym) captured at Chuncheon, South Korea

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Laboratory inbred mice are used widely and commonly in biomedical research, but inbred mice do not have a big enough gene pool for the research. In this study, genetic and morphometric analyses were performed to obtain data on the characteristics of a newly developing inbred strain (KWM/Hym) captured from Chuncheon, Korea. All of five Korean wild male mice have the zinc-finger Y (ZfY) gene. Also, all of 19 Korean wild mice used in this analysis have the AKV-type murine leukemia virus gene, indicating that Korean wild mice might be Mus musculus musculus. To identify the genetic polymorphism in KWM/Hym, SNP analysis was performed. In a comparison with 28 SNP markers, there was a considerable difference between KWM/Hym and several inbred strains. The homogeneity between KWM/Hym and the inbred strains was as follows: C57BL/6J (39.3%), BALB/c AJic (42.9%), and DBA/2J (50%). KWM/Hym is most similar to the PWK/PhJ inbred strain (96.4%) derived from wild mice (Czech Republic). To identify the morphometric characteristics of KWM/Hym, the external morphology was measured. The tail ratio of male and female was 79.60±3.09 and 73.55±6.14%, respectively. KWM/Hym has short and agouti-colored hairs and its belly is white with golden hair. Taking these results together, KWM/Hym, a newly developing inbred mouse originated from wild mouse, might be use as new genetic resources to overcome the limitations of the current laboratory mice.


  1. 1.

    Bedell MA, Jenkins NA, Copeland NG. Mouse models of human disease. Part I: techniques and resources for genetic analysis in mice. Genes Dev 1997; 11(1): 1–10.

  2. 2.

    The mouse in biomedical research, 2nd Edition. Academic Press, 2006.

  3. 3.

    Abe K, Noguchi H, Tagawa K, Yuzuriha M, Toyoda A, Kojima T, Ezawa K, Saitou N, Hattori M, Sakaki Y, Moriwaki K, Shiroishi T. Contribution of Asian mouse subspecies Mus musculus molossinus to genomic constitution of strain C57BL/6J, as defined by BAC-end sequence-SNP analysis. Genome Res 2004; 14(12): 2439–2447.

  4. 4.

    Reardon S. Frustrated Alzheimer’s researchers seek better lab mice. Nature 2018; 563(7733): 611–612.

  5. 5.

    Schwarz E, Schwarz HK. The wild and commensal stocks of the house mouse, Mus musculus. J Mammal 1943; 24: 59–72.

  6. 6.

    Boursot P, Auffray JC, Britton-Davidian J, Bonhomme F. The evolution of house mice. Annu Rev Ecol Syst 1993; 24: 119–152.

  7. 7.

    Bonhomme F, Catalan J, Britton-Davidian J, Chapman VM, Moriwaki K, Nevo E, Thaler L. Biochemical diversity and evolution in the genus Mus. Biochem Genet 1984; 22(3–4): 275–303.

  8. 8.

    Yonekawa H, Moriwaki K, Gotoh O, Hayashi JI, Watanabe J, Miyashita N, Petras ML, Tagashira Y. Evolutionary relationships among five subspecies of Mus musculus based on restriction enzyme cleavage patterns of mitochondrial DNA. Genetics 1981; 98(4): 801–816.

  9. 9.

    Suzuki H, Miyashita N, Moriwaki K, Kominami R, Muramatsu M, Kanehisa T, Bonhomme F, Petras ML, Yu ZC, Lu DY. Evolutionary implication of heterogeneity of the nontranscribed spacer region of ribosomal DNA repeating units in various subspecies of Mus musculus. Mol Biol Evol 1986; 3(2): 126–137.

  10. 10.

    Moriwaki K, Shiroishi T, Yonekawa H. Wild mouse from a geneticist’s viewpoint. In: Genetics in Wild Mice. Japan Scientific Societies Press, Tokyo: Karger, 1994; pp 13–25.

  11. 11.

    Lee YH, Park JY, Yun YM, Oh SH, Lee JE, Jin HK, Do SG, Suh JG, Lee CH, Hyun BH, Oh YS, Seong JK. Genetic characteristics of Korean wild mice (Mus musculus spp.) by biochemical marker gene. Lab Anim Res 2000; 16(1): 33–39.

  12. 12.

    Duplantier JM, Orth A, Catalan J, Bonhomme F. Evidence for a mitochondrial lineage originating from the Arabian peninsula in the Madagascar house mouse (Mus musculus). Heredity (Edinb) 2002; 89(2): 154–158.

  13. 13.

    Petkov PM, Cassell MA, Sargent EE, Donnelly CJ, Robinson P, Crew V, Asquith S, Haar RV, Wiles MV. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 2004; 83(5): 902–911.

  14. 14.

    Shao Y, Wang J, Qiao Y, He Y, Cao W. Morphological variability between wild populations and inbred stocks of a Chinese minnow, Gobiocypris rarus. Zoolog Sci 2007; 24(11): 1094–1102.

  15. 15.

    Yom-Tov Y, Geffen E. Geographic variation in body size: the effects of ambient temperature and precipitation. Oecologia 2006; 148(2): 213–218.

  16. 16.

    Berry RJ. Natural history of the house mouse. Field Studies Council, 1970; 3: pp 219–262.

  17. 17.

    Hwang SH, Cho KI, Park JH, Ryoo ZY, Oh YS, Suh JG. Studies on distribution of the Zfy, Fv4r, and AKV-type MuLV genes in Korean wild mice. Lab Anim Res 2005; 21(2): 135–139.

  18. 18.

    Marshall JT. Taxonomy in “The mouse in biomedical research”. Academic Press, 1981; pp 17–26.

  19. 19.

    Auffray C, Tchernov E, Bonhomme F, Giora Heth S, Simson S, Nevo E. Presence and ecological distribution of Mus “spretoides” and Mus musculus domesticus in Israel-Circum-Mediterranean vicariance in the genus Mus. Z. Saugetierkunde 1990; 55: 1–10.

  20. 20.

    Boursot P, Din W, Anand R, Darviche D, Dod B, Von Deimling F, Talwar GP, Bonhomme F. Origin and radiation of the house mouse: mitochondrial DNA phylogeny. J of Evolutionary Biology 1996; 9(4): 391–415.

  21. 21.

    Barton NH, Keightley PD. Understanding quantitative genetic variation. Nat Rev Genet 2002; 3(1): 11–21.

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Correspondence to Jun Gyo Suh.

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Nam, H., Kim, Y.Y., Kim, B. et al. Genetic and morphometric characteristics of Korean wild mice (KWM/Hym) captured at Chuncheon, South Korea. Lab Anim Res 34, 311–316 (2018).

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  • Korean wild mouse
  • Mus musculus
  • subspecies
  • polymorphism
  • genetic resources