Laboratory Animal Research

Comparison of cisplatin-induced anti-tumor response in CT26 syngeneic tumors of three BALB/c substrains

To determine whether the background of BALB/c substrains affects the response to anti-tumor drugs, authors measured for alterations in tumor growth, histopathological structure of the tumor, and expressions of tumor-related proteins in three BALB/c substrains derived from different sources, after exposure to varying concentrations of cisplatin.

Jeong Eun Gong, You Jung Jin, Ji Eun Kim, Yun Ju Choi, Su Jin Lee, Kil Soo Kim, Young Suk Jung, Joon Yong Cho, Yong Lim, Hyun Gu Kang & Dae Youn Hwang 

Volume 37, Article number: 33 (2021)

Sensitivity to tumor development by TALEN-mediated Trp53 mutant genes in the susceptible FVB/N mice and the resistance C57BL/6 mice

This study was undertaken to compare the sensitivities of mice strains during tumor induction by transcription activator-like effector nucleases (TALEN)-mediated Trp53 mutant gene. Alterations of their tumorigenic phenotypes including survival rate, tumor formation and tumor spectrum, were assessed in FVB/N-Trp53em2Hwl/Korl and C57BL/6-Trp53em1Hwl/Korl knockout (KO) mice over 16 weeks.

Woo Bin Yun, Ji Eun Kim, Mi Lim Lee, Jun Young Choi, Jin Ju Park, Bo Ram Song, Byeong Cheol Kang, Ki Taek Nam, Han-Woong Lee & Dae Youn Hwang

Vol. 37, Article number: 32 (2021)

Insight into the emerging and common experimental in-vivo models of Alzheimer’s disease

Alzheimer’s disease (AD) is a multifactorial, rapidly progressing neurodegenerative disorder. As the exact cause of the disease is still unclear, the drug development is very challenging. This review encompasses the commonly used AD models involving various chemicals, heavy metals and endogenous substances induced models and the transgenic models.

Rishika Dhapola, Sneha Kumari, Prajjwal Sharma, Dibbanti HariKrishnaReddy 

Volume 39, Article number: 33 (2023)

Total citations: 4 (on 20th August, 2024)
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Role of animal models in biomedical research: a review

The animal model deals with the species other than the human, as it can imitate the disease progression, its’ diagnosis as well as a treatment similar to human. Discovery of a drug and/or component, equipment, their toxicological studies, dose, side effects are in vivo studied for future use in humans considering its’ ethical issues.

Mukherjee, P.; Roy, S.; Ghosh, D.; Nandi, S. K.

Volume 38, Article number: 18 (2022)

Total citations: 91 (on 20 August, 2024)
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Laboratory Animal Research (LAR) is the official journal of KALAS.
KALAS sponsors full amount of APC for all the articles accepted for publication so that the authors do not need to pay.

Laboratory Animal Research (LAR) was founded in 1985 as the official journal of The Korean Association for Laboratory Animal Science (KALAS). In 2019 it started publishing contents in fully open access format.
This website now hosts the articles published after 2015. The legacy contents published in 2010-2014 are available at KoreaMed Synapse.