Fig. 2

Representative histopathological images of skin from mice treated ADFE or vehicle. Two mouse skin samples per group were stained with hematoxylin and eosin (scale bar = 50 μm, 100X magnification). The aAD(-) and aAD(-)/ADFE showed no evidence of acute atopic dermatitis induction, regardless of ADFE treatment. The aAD( +) and aAD( +)/ADFE groups showed induction of acute atopic dermatitis regardless of ADFE treatment. The cAD( +)/EtOH and cAD( +)/ADFE groups were exposed to 10% ethanol or ADFE. The yellow letters E and D in left panel of (A) denote the epidermal and dermal layer, respectively. ADFE, Artemisia dubia folium extract; aAD(-), no acute atopic dermatitis induction; aAD( +), aAD induction; aAD(-)/ADFE, no aAD induction but ADFE treatment; aAD( +)/ADFE, aAD induction with ADFE treatment; cAD( +)/EtOH, chronic AD induction with 10% EtOH application; cAD( +)/ADFE, cAD induction with ADFE treatment