Evaluation of Artemisia dubia folium extract-mediated immune efficacy through developing a murine model for acute and chronic stages of atopic dermatitis

Table 1 Hematologic parameters in mice with acute or chronic atopic dermatitis treated (or not) with ADFE

Group	WBC (× 10³/μl)	Neutrophils (%)	Lymphocytes (%)	Monocytes (%)	Eosinophils (%)	Basophils (%)
aAD(-)	4.75 ± 3.17	23.90 ± 12.59	66.12 ± 14.55	2.93 ± 1.49	5.15 ± 2.13	1.23 ± 1.12
aAD(-)/EtOH	4.03 ± 0.71	22.60 ± 6.51	59.02 ± 14.59	1.18 ± 0.15	2.68 ± 0.99	0.58 ± 0.17
aAD(-)/ADFE	3.54 ± 1.42	25.56 ± 2.38	66.70 ± 1.90	1.43 ± 0.21	4.20 ± 0.46	0.43 ± 0.23
aAD( +)	9.32 ± 6.80	29.05 ± 13.36	62.80 ± 13.85	3.20 ± 0.99	2.10 ± 0.14	1.00 ± 0.28
aAD( +)/EtOH	5.65 ± 0.79	21.27 ± 7.54	69.25 ± 9.96	1.75 ± 0.39	5.55 ± 2.46	0.48 ± 0.10
aAD( +)/ADFE	5.82 ± 1.23	27.60 ± 3.54	63.75 ± 3.89	2.50 ± 0.42	3.95 ± 0.92	0.75 ± 0.35
cAD( +)/EtOH	4.15 ± 2.05	25.80 ± 6.86	64.80 ± 5.69	2.60 ± 0.77	3.60 ± 0.53	0.82 ± 0.50
cAD( +)/ADFE	3.94 ± 1.34	27.96 ± 9.12	64.68 ± 9.32	1.76 ± 0.22	2.56 ± 0.52	0.34 ± 0.05

Blood was collected at the time of sacrifice (Day 28 for the aAD groups and Day 42 for the cAD groups). Data represent the mean ± SD (five mice per group)
ADFE Artemisia dubia folium extract, WBC White blood cells, aAD(-), no Acute atopic dermatitis induction, aAD(-)/EtOHi no aAD induction but 10% EtOH vehicle application, aAD(-)/ADFE no aAD induction but ADFE treatment, aAD( +) aAD induction, aAD( +)/EtOH aAD induction with 10% EtOH application, aAD( +)/ADFE aAD induction with ADFE treatment, cAD( +)/EtOH Chronic AD induction with 10% EtOH application, cAD( +)/ADFE cAD induction with ADFE treatment

ISSN: 2233-7660