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  1. Ankylosis in the temporomandibular joint (TMJ) is known to have various etiologies in veterinary medicine. We observed a case of fibrous ankylosis of the TMJ in a newly imported rhesus monkey (Macaca mulatta).

    Authors: Su-Mi Kim, Chang-Gok Woo and Jong-Min Kim
    Citation: Laboratory Animal Research 2020 36:19
    Content type: Case Report Published on:

  3. To date, researchers have developed various animal models of Alzheimer’s disease (AD) to investigate its mechanisms and to identify potential therapeutic treatments. A widely recognized model that mimics the p...

    Authors: Yujin Ahn, Jincheol Seo, Junghyung Park, Jinyoung Won, Hyeon-Gu Yeo, Keonwoo Kim, Chang-Yeop Jeon, Jae-Won Huh, Sang-Rae Lee, Dong-Seok Lee and Youngjeon Lee
    Citation: Laboratory Animal Research 2020 36:17
    Content type: Research Published on:

  5. Excessive alcohol consumption induces acute intoxication and various hepatic diseases. In this study, we investigated the effect of the CureZyme-ACE (CA), Acetobacter Pasteurianus (AP)-derived product, in acute i...

    Authors: Eun-Jong Jeon, Yun-Sang Cho, Ae-Hyang Kim, Jae-Min Shim, Yi-Soo Kim, Zhe Piao, Young Chul Shin and Jungkee Kwon
    Citation: Laboratory Animal Research 2020 36:15
    Content type: Research Published on:

  7. Much of medical research relies on animal models to deepen knowledge of the causes of animal and human diseases, as well as to enable the development of innovative therapies. Despite rodents being the most wid...

    Authors: Ricardo Lacava Bailone, Hirla Costa Silva Fukushima, Bianca Helena Ventura Fernandes, Luís Kluwe De Aguiar, Tatiana Corrêa, Helena Janke, Princia Grejo Setti, Roberto De Oliveira Roça and Ricardo Carneiro Borra
    Citation: Laboratory Animal Research 2020 36:13
    Content type: Review Published on:

  9. Pandemics affect human lives severely and globally. Experience predicts that there will be a pandemic for sure although the time is unknown. When a viral epidemic breaks out, assessing its pandemic risk is an ...

    Authors: Mee Sook Park, Jin Il Kim, Joon-Yong Bae and Man-Seong Park
    Citation: Laboratory Animal Research 2020 36:11
    Content type: Review Published on:

  10. Extracellular vesicles (EVs) are nano-sized particles secreted by almost all cell types, and they mediate various biological processes via cell-to-cell communication. Compared with parental cells for therapeut...

    Authors: Ki Hoon Kim, Jeong Hyun Jo, Hye Jin Cho, Tae Sub Park and Tae Min Kim
    Citation: Laboratory Animal Research 2020 36:10
    Content type: Review Published on:

  11. Psychiatric disorders are a prevalent global health problem, over 900 million individuals affected by a continuum of mental and substance use disorders. Due to this high prevalence, and the substantial direct ...

    Authors: Matthew Baker, Sa-Ik Hong, Seungwoo Kang and Doo-Sup Choi
    Citation: Laboratory Animal Research 2020 36:9
    Content type: Review Published on:

  13. Dementia is defined as cognitive impairment in more than one cognitive area and leads to an abnormal degree of impairment in the ability to remember past events. Among mice models of dementia the most used str...

    Authors: Nashelly Esquivel, Yenela García, Bestraida Lores, Marivy Gutiérrez and Claudio Rodríguez
    Citation: Laboratory Animal Research 2020 36:7
    Content type: Research Published on:

  15. To investigate the role of complement C3 (C3) convertase on the strain difference for C3 protein expression in three inbred mice strains, we compared the levels of C2, C3 and C4 mRNA, as well as C3 protein and...

    Authors: Ji Won Park, Ji Eun Kim, Mi Ju Kang, Hyeon Jun Choi, Su Ji Bae and Dae Youn Hwang
    Citation: Laboratory Animal Research 2020 36:4
    Content type: Research Published on:

  18. To investigate conditions that cause temporal lens opacity, we tested chemical and physical factors, such as anaesthesia dose, ocular surface dryness, and infrared (IR) light exposure in anaesthetised C57BL/6 ...

    Authors: Hun Lee, Hong Kyung Kim, Hae Sol Shin, Soo Jung Han, Sangchul Yoon, Je Kyung Seong and Kyoung Yul Seo
    Citation: Laboratory Animal Research 2020 36:1
    Content type: Research Published on:

  19. The butanol extract of Asparagus cochinchinensis roots fermented with Weissella cibaria (BAW) effectively prevents inflammation and remodeling of airway in the ovalbumin (OVA)-induced asthma model. To characteriz...

    Authors: Jun Young Choi, So Hyun Kim, Ji Eun Kim, Ji Won Park, Mi Ju Kang, Hyeon Jun Choi, Su Ji Bae, Jae Ho Lee, Young-Suk Jung and Dae Youn Hwang
    Citation: Laboratory Animal Research 2019 35:32
    Content type: Research Published on:

  20. Although the number of prescriptions and dependence on sleeping pills are increasing, the associations with unexpected abnormal behaviors and metabolic diseases caused by the overuse of sleeping pills are not ...

    Authors: Gwang-Ho Kim and Sun Shin Yi
    Citation: Laboratory Animal Research 2019 35:31
    Content type: Research Published on:

  21. Signal transducer and activator of transcription 3 (STAT3) modulates a variety of genes involved in the regulation of critical functions, including cell proliferation, differentiation, apoptosis, angiogenesis,...

    Authors: Ju-Hee Kang, Yeong-Su Jang, Ha Jung Lee, Chang-Yong Lee, Dong Yun Shin and Seung Hyun Oh
    Citation: Laboratory Animal Research 2019 35:30
    Content type: Research Published on:

  22. Coffee is one of the most commonly consumed beverages in the worldwide and is assumed to have protective effects against metabolic syndrome. The present study was aimed at investigating the effect of coffee on...

    Authors: Teka Obsa Feyisa, Daniel Seifu Melka, Menakath Menon, Wajana Lako Labisso and Mezgebu Legesse Habte
    Citation: Laboratory Animal Research 2019 35:29
    Content type: Research Published on:

  23. In this probe, at first we examined the best route and dosage of arginine administration on wound healing in an excisional wound model in rats. Next, we intend to assess the impact of photobiomodulation (PBM) ...

    Authors: Atarodsadat Mostafavinia, Mohammad Bidram, Amirhossein Gomi Avili, Mohammadamin Mahmanzar, Seyed Ali Karimifard, Ensieh Sajadi, Abdollah Amini, Mahsa Hadipour Jahromy, Seyed Kamran Ghoreishi, Sufan Chien and Mohammad Bayat
    Citation: Laboratory Animal Research 2019 35:28
    Content type: Research Published on:

  24. TW-37 is a small molecule B cell lymphoma-2 (Bcl-2) homology 3 mimetic with potential anticancer activities. However, the in vivo anti-cancer effect of TW-37 in human oral cancer has not been properly studied ...

    Authors: Chi-Hyun Ahn, Won Woo Lee, Yun Chan Jung, Ji-Ae Shin, Kyoung-Ok Hong, Sujung Choi, Neeti Swarup, Jihoon Kim, Min-Hye Ahn, Minjung Jung, Sung-Dae Cho and Bohwan Jin
    Citation: Laboratory Animal Research 2019 35:27
    Content type: Research Published on:

  25. Emerging evidences have reported that periodontitis can be a risk factor for the pathogenesis of various systemic diseases. Porphyromonas gingivalis (Pg), one of the crucial pathogens in chronic periodontitis, ha...

    Authors: Yoojin Seo, Su-Jeong Oh, Ji-Su Ahn, Ye Young Shin, Ji Won Yang and Hyung-Sik Kim
    Citation: Laboratory Animal Research 2019 35:26
    Content type: Research Published on:

  27. Glutamate leads to neuronal cell damage by generating neurotoxicity during brain development. The objective of this study is to identify proteins that differently expressed by glutamate treatment in neonatal c...

    Authors: Ju-Bin Kang, Dong-Ju Park and Phil-Ok Koh
    Citation: Laboratory Animal Research 2019 35:24
    Content type: Research Published on:

  28. Genetically engineered mouse models are used in high-throughput phenotyping screens to understand genotype-phenotype associations and their relevance to human diseases. However, not all mutant mouse lines with...

    Authors: Daejin Hyung, Ann-Marie Mallon, Dong Soo Kyung, Soo Young Cho and Je Kyung Seong
    Citation: Laboratory Animal Research 2019 35:23
    Content type: Research Published on:

  30. In the present study, we investigated the effects of heat shock protein 70 (HSP70) on novel object recognition, cell proliferation, and neuroblast differentiation in the hippocampus. To facilitate penetration ...

    Authors: Hyun Jung Kwon, Woosuk Kim, Hyo Young Jung, Min Soo Kang, Jong Whi Kim, Kyu Ri Hahn, Dae Young Yoo, Yeo Sung Yoon, In Koo Hwang and Dae Won Kim
    Citation: Laboratory Animal Research 2019 35:21
    Content type: Research Published on:

  31. P53 and its family member p63 play important roles in cellular senescence and organismal aging. In this study, p53 and p63 immunoreactivity were examined in the hippocampus of young, adult and aged mice by usi...

    Authors: Tae-Kyeong Lee, Young Eun Park, Cheol Woo Park, Bora Kim, Jae-Chul Lee, Joon Ha Park, Hyang-Ah Lee, Moo-Ho Won and Ji Hyeon Ahn
    Citation: Laboratory Animal Research 2019 35:20
    Content type: Research Published on:

  32. Lipopolysaccharide (LPS) acts as an endotoxin, releases inflammatory cytokines, and promotes an inflammatory response in various tissues. This study investigated whether LPS modulates neuroglia activation and ...

    Authors: Ju-Bin Kang, Dong-Ju Park, Murad-Ali Shah, Myeong-Ok Kim and Phil-Ok Koh
    Citation: Laboratory Animal Research 2019 35:19
    Content type: Research Published on:

  33. Cerebral ischemia is a major cause of neurodegenerative disease. It induces neuronal vulnerability and susceptibility, and leads to neuronal cell death. Resveratrol is a polyphenolic compound that acts as an a...

    Authors: Dong-Ju Park, Ju-Bin Kang, Fawad-Ali Shah and Phil-Ok Koh
    Citation: Laboratory Animal Research 2019 35:18
    Content type: Research Published on:

  34. In our efforts to understand the systemic features of tumors, the importance of animal models is increasing due to the recent growth in the development of immunotherapy and targeted therapies. This has resulte...

    Authors: Mi Ju Kang, Ji Eun Kim, Ji Won Park, Hyeon Jun Choi, Su Ji Bae, Kil Soo Kim, Young-Suk Jung, Joon-Yong Cho, Dae Youn Hwang and Hyun Keun Song
    Citation: Laboratory Animal Research 2019 35:17
    Content type: Research Published on:

  35. Acetaminophen (APAP) is the most common antipyretic analgesic worldwide. However, APAP overdose causes severe liver injury, especially centrilobular necrosis, in humans and experimental animals. At therapeutic...

    Authors: Tae Bin Jeong, Joung-Hee Kim, Sou Hyun Kim, Seunghyun Lee, Seung Won Son, Yong Lim, Joon-Yong Cho, Dae Youn Hwang, Kil Soo Kim, Jae-Hwan Kwak and Young-Suk Jung
    Citation: Laboratory Animal Research 2019 35:16
    Content type: Research Published on:

  36. Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease worldwide. It is characterized by the accumulation of lipids without alcohol intake and often progresses to non-alcoholic...

    Authors: Seunghyun Lee, Jae-Hwan Kwak, Sou Hyun Kim, Tae Bin Jeong, Seung Won Son, Joung-Hee Kim, Yong Lim, Joon-Yong Cho, Dae Youn Hwang, Kil Soo Kim and Young-Suk Jung
    Citation: Laboratory Animal Research 2019 35:15
    Content type: Research Published on:

  38. A total of 24 SD rats were allotted to four treatment groups such as the control (CON), 1% of cholesterol diet (CHO), 0.5% of coenzyme Q10 (COQ) and 1% of cholesterol plus 0.5% of coenzyme Q10 (CHCQ) groups to de...

    Authors: Ha-Na Kim, Dong-Gyung Jeon, Yong Lim and In-Surk Jang
    Citation: Laboratory Animal Research 2019 35:13
    Content type: Research Published on:

  39. Histone-binding protein RbAp48 has been known to be involved in histone acetylation, and epigenetic alterations of histone modifications are closely associated with the pathogenesis of ischemic reperfusion inj...

    Authors: Joon Ha Park, Tae-Kyeong Lee, Dae Won Kim, Cheol Woo Park, Young Eun Park, Bora Kim, Jae-Chul Lee, Hyang-Ah Lee, Moo-Ho Won and Ji Hyeon Ahn
    Citation: Laboratory Animal Research 2019 35:12
    Content type: Research Published on:

  40. Botulinum-toxin A (BoNT/A) is a widely used not only for cosmetics but also for various experimental purposes including muscle-related research. In this study, we applied BoNT/A to mouse muscle of three differ...

    Authors: Min-Soo Seo, Young-In Kim, Kyung-Ku Kang, Se-Kyung Oh, Soo-Eun Sung, Young-Suk Jung, Joon Yong Cho, HyunKeun Song, Dae Youn Hwang, Sang-Joon Park and Kil Soo Kim
    Citation: Laboratory Animal Research 2019 35:11
    Content type: Research Published on:

  41. MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is commonly used to induce nigrostriatal defects to induce parkinsonism and/or parkinsonian syndrome, to replicate the lesions seen in Parkinson’s disease (PD...

    Authors: Dong-Joo Hwang, Ki-Chun Kwon, Hyun-Keun Song, Kil-Soo Kim, Young-Suk Jung, Dae-Youn Hwang and Joon-Yong Cho
    Citation: Laboratory Animal Research 2019 35:10
    Content type: Research Published on:

  42. Red Liriope platyphylla (RLP) is a known herbal medicine used in the treatment of some chronic diseases including constipation, neurodegenerative disorders, diabetes and obesity. To determine and characterize put...

    Authors: Ji Eun Kim, Young Ju Lee, Sung Ha Ryu, Ji Won Park, Mi Ju Kang, Hyeon Jun Choi, Su Ji Bae, Yusang Choi, Hyun Gu Kang, Kyu-Bong Kim, Suhkmann Kim, Yong Lim and Dae Youn Hwang
    Citation: Laboratory Animal Research 2019 35:9
    Content type: Research Published on:

  44. Nonhuman primate models are valuable in biomedical research. However, reference data for clinical pathology parameters in cynomolgus and rhesus monkeys are limited. In the present study, we established hematol...

    Authors: Bon-Sang Koo, Dong-Ho Lee, Philyong Kang, Kang-Jin Jeong, Sangil Lee, Kijin Kim, Youngjeon Lee, Jae-Won Huh, Young-Hyun Kim, Sang-Je Park, Yeung Bae Jin, Sun-Uk Kim, Ji-Su Kim, Yeonghoon Son and Sang-Rae Lee
    Citation: Laboratory Animal Research 2019 35:7
    Content type: Research Published on:

  45. Toxoplasmosis is a disease caused by the protozoan Toxoplasma gondii, which occurs worldwide in mammals and birds. Brain is the primary target organ because Toxoplasma gondii is a ubiquitous intracellular parasit...

    Authors: Hasan Tarik Atmaca, Aycan Nuriye Gazyagci, Osman Safa Terzi, Gungor Cagdas Dincel and Tugce Sumer
    Citation: Laboratory Animal Research 2019 35:6
    Content type: Research Published on:

  46. Streptococcus pneumoniae causes many people to suffer from pneumonia, septicemia, and other diseases worldwide. To identify the difference in susceptibility of and treatment efficacy against S. pneumoniae in thre...

    Authors: Jun-Young Kim, Sun-Min Seo, Han-Kyul Lee, Han-Woong Kim and Yang-Kyu Choi
    Citation: Laboratory Animal Research 2019 35:5
    Content type: Research Published on:

  47. Although Eriobotrya japonica leaves have been studied as a raw material for various cosmetic products, little is known about the anti-oxidant, anti-inflammatory, and anti-melanogenic activities of Eriobotrya japo...

    Authors: Nak-Won Seong, Won-Jun Oh, Il-Soo Kim, Su-Jin Kim, Ji-Eun Seo, Chang-Eon Park, Da-Young Kim, Je-Won Ko and Jong-Choon Kim
    Citation: Laboratory Animal Research 2019 35:4
    Content type: Research Published on:

  48. Iran bears a remarkable variety of reptiles. One of the lizard families occurring in Iran is the Family Agamidae which is widely are distributed throughout the old world. The large-scaled rock agamid, Laudakia nu...

    Authors: Farkhondeh Sayyadi, Nasrullah Rastegar-Pouyani, Mehri Azadbakht and Khosrow Chehri
    Citation: Laboratory Animal Research 2019 35:3
    Content type: Research Published on:

  49. We examined the precision, accuracy, and capability of detecting changes of Dual-Energy X-ray Absorptiometry (DXA) for the measurements of total-body weight (TBW), total-body fat weight (TBFW), and total-body ...

    Authors: Jungyun Yeu, Han-Jik Ko, Doyeun Kim, Youngbok Ahn, Jaejin Kim, Wonhee Lee, IlSin Jung, Jungkyu Suh and Seok-Jong Lee
    Citation: Laboratory Animal Research 2019 35:2
    Content type: Research Published on:
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  • Laboratory Animal Research is the official journal of the Korean Association for Laboratory Animal Science. KALAS was established in 1985 in order to discuss the knowledge of the experiment, and promote the science and technology in laboratory animal sciences.

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Laboratory Animal Research

ISSN: 2233-7660