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  2. Anesthesia and analgesia are major components of many interventional studies on laboratory animals. However, various studies have shown improper reporting or use of anesthetics/analgesics in research proposals...

    Authors: Siavash Ahmadi-Noorbakhsh, Mohammad Farajli Abbasi, Maedeh Ghasemi, Gholamreza Bayat, Nahid Davoodian, Ehsan Sharif-Paghaleh, Seyedeh Mahsa Poormoosavi, Melika Rafizadeh, Maryam Maleki, Hesamaddin Shirzad-Aski, Hossein Kargar Jahromi, Masoomeh Dadkhah, Bahman Khalvati, Tahereh Safari, Mohammad Amin Behmanesh, Seyed Esmaeil Khoshnam…
    Citation: Laboratory Animal Research 2022 38:40
    Content type: Review Published on:

  3. Fameyes (a mixture of Clematis mandshurica Rupr. extract (CMRE) and Erigeron annuus (L.) Pers. extract (EAPE)) containing scutellarin and chlorogenic acid as major components has been reported to relieve mental s...

    Authors: Junkee Hong, Tae-Kyeong Lee, In Hye Kim, Seungah Lee, Byung-Ju Jeon, Jiwon Lee, Moo-Ho Won and Sungsu Kim
    Citation: Laboratory Animal Research 2022 38:39
    Content type: Research Published on:

  6. Resistance exercise training is known to improve metabolic disorders, such as obesity and type2 diabetes. In this study, we investigated whether the beneficial effects of resistance exercise training persisted...

    Authors: Hye Jin Kim, Youn Ju Kim, Il Yong Kim and Je Kyung Seong
    Citation: Laboratory Animal Research 2022 38:36
    Content type: Research Published on:

  7. Obstructive jaundice induces oxidative changes in the brain parenchyma and plays significant role in clinical manifestations of hepatic encephalopathy. We aim to study the progression of the brain oxidative st...

    Authors: Konstantinos Lilimpakis, Aidona Tsepelaki, Electra Kalaitzopoulou, Dimitrios Zisimopoulos, Polyxeni Papadea, Marianna Skipitari, Athina Varemmenou, Apostolos Aggelis, Constantine Vagianos, Constantine Constantoyannis and Christos D. Georgiou
    Citation: Laboratory Animal Research 2022 38:35
    Content type: Research Published on:

  8. The Asian federation of laboratory animal science associations (AFLAS) was established on November 29, 2003, and will celebrate its 20th anniversary in 2023. During this time, the number of AFLAS member associ...

    Authors: Noriyuki Kasai
    Citation: Laboratory Animal Research 2022 38:34
    Content type: Review Published on:

  9. Nonhuman primates are used for research purposes such as studying diseases and drug discovery and development programs. Various clinical pathology parameters are used as biomarkers of disease conditions in bio...

    Authors: Niraj A. Shah, Laxit K. Bhatt, Rajesh J. Patel, Tushar M. Patel, Nayankumar V. Patel, Harshida G. Trivedi, Nilam R. Patel, Jitendra H. Patel, Satish D. Patel, Rajesh S. Sundar and Mukul R. Jain
    Citation: Laboratory Animal Research 2022 38:33
    Content type: Research Published on:

  10. In vivo molecular imaging is a research field in which molecular biology and advanced imaging techniques are combined for imaging molecular-level biochemical and physiological changes that occur in a living bo...

    Authors: Su Jin Kim and Ho-Young Lee
    Citation: Laboratory Animal Research 2022 38:31
    Content type: Review Published on:

  11. Given its similar structure and immune response to the human skin, porcine is a good model for dermal studies. Here, we sensitized ovalbumin (Ova) on minipig back skin for 2–4 weeks to induce chronic atopic de...

    Authors: Young Kyu Kim, JuKyung Lee, Hyeon-Young Kim, Sung-Hwan Kim, Jeong Ho Hwang and Han Na Suh
    Citation: Laboratory Animal Research 2022 38:32
    Content type: Research Published on:

  12. All mouse strains are different, before choosing a strain for a large study, a small scale study should be done. In this study, we compared young males of two mouse strains, C57BL/6J and the hybrid B6129SF1/J,...

    Authors: Kristine Eraker Aasland Hansen, Alexandra M. Hudecová, Fred Haugen, Eystein Skjerve, Erik Ropstad and Karin E. Zimmer
    Citation: Laboratory Animal Research 2022 38:30
    Content type: Research Published on:

  13. Now that it is possible to efficiently classify and save tissue images of laboratory animals using whole-slide imaging, many diagnostic models are being developed through transfer learning with Convolutional N...

    Authors: Jong Su Byun, Ji Hyun Lee, Jin Seok Kang and Beom Seok Han
    Citation: Laboratory Animal Research 2022 38:29
    Content type: Research Published on:

  14. Inbred mice have several advantages, including genetic similarity to humans, a well-established gene manipulation system, and strong tolerance to inbreeding. However, inbred mice derived from a limited genetic...

    Authors: Hajin Nam, Boyoung Kim, Avishekh Gautam, Yoo Yeon Kim, Eun Sun Park, Jong Sun Lee, Hyung-Joo Kwon, Je Kyung Seong and Jun Gyo Suh
    Citation: Laboratory Animal Research 2022 38:28
    Content type: Research Published on:

  15. The Institutional Animal Care and Use Committee (IACUC) became compulsory in 2008 by the Animal Protection Act in Korea. Seoul National University (SNU), which conducts 5% of Korea’s total animal protocol revi...

    Authors: Na Ahn, Jaehak Park, Jungjoon Ihm and Sangho Roh
    Citation: Laboratory Animal Research 2022 38:27
    Content type: Research Published on:

  16. Calcium carbide (CaC2) is a chemical primarily used in the production of acetylene gas. The misuse of CaC2 to induce fruit ripening is a global challenge with a potential adverse effects to human health. Addition...

    Authors: Pherah A. Ouma, Victoria K. Mwaeni, Peris W. Amwayi, Alfred Orina Isaac and James Nyabuga Nyariki
    Citation: Laboratory Animal Research 2022 38:26
    Content type: Research Published on:

  18. Rabbits are being increasingly used as companion animals, and in research; thus, the need for proper veterinary care for rabbits has increased. Surgical access is more challenging in rabbits under inhalation a...

    Authors: Yujin Kim, Hee Yeon Jeon, Insook Yang, Ji Hyun Kim, Jae Hee Chung, Ji-Hyeon Ju, Gyeonghun Kim, Jun Won Park, Seung Yeon Oh, Je Kyung Seong, Seung Hyun Oh and Young-Shin Joo
    Citation: Laboratory Animal Research 2022 38:24
    Content type: Short Communication Published on:

  19. Mechanical ventilation is a life-saving therapy for critically ill patients, providing rest to the respiratory muscles and facilitating gas exchange in the lungs. Ventilator-induced lung injury (VILI) is an un...

    Authors: Jon Petur Joelsson, Arni Asbjarnarson, Snaevar Sigurdsson, Jennifer Kricker, Bryndis Valdimarsdottir, Holmfridur Thorarinsdottir, Eir Starradottir, Thorarinn Gudjonsson, Saevar Ingthorsson and Sigurbergur Karason
    Citation: Laboratory Animal Research 2022 38:23
    Content type: Research Published on:

  20. To systematically evaluate the effects of metformin on tumors in experimental animal models of different types of cancer. Pubmed, Embase, Cochrane, and Web of Science databases were searched for studies on met...

    Authors: Fan Zhang, Shuai Han and Weijie Song
    Citation: Laboratory Animal Research 2022 38:22
    Content type: Short Communication Published on:

  21. Neuroinflammation plays an important role in cognitive decline and memory impairment in neurodegenerative disorders. Previously, we demonstrated that Humulus japonicus (HJ) has anti-inflammatory effects in rodent...

    Authors: Jun Go, Hye-Yeon Park, Da Woon Lee, So-Young Maeng, In-Bok Lee, Yun Jeong Seo, Jin-Pyo An, Won Keun Oh, Chul-Ho Lee and Kyoung-Shim Kim
    Citation: Laboratory Animal Research 2022 38:21
    Content type: Research Published on:

  22. Gastrointestinal microbiota, which comprises hundreds of different types of microbes, biologically plays crucial roles in the host’s health. Probiotics (PRO) did not always have a positive benefit on the host,...

    Authors: Min-Jeong Kim, Dong-Gyeong Jeon, Yong Lim and Insurk Jang
    Citation: Laboratory Animal Research 2022 38:20
    Content type: Research Published on:

  24. The animal model deals with the species other than the human, as it can imitate the disease progression, its’ diagnosis as well as a treatment similar to human. Discovery of a drug and/or component, equipment,...

    Authors: P. Mukherjee, S. Roy, D. Ghosh and S. K. Nandi
    Citation: Laboratory Animal Research 2022 38:18
    Content type: Review Published on:

  25. As the number of large-scale studies involving multiple organizations producing data has steadily increased, an integrated system for a common interoperable format is needed. In response to the coronavirus dis...

    Authors: Suhyeon Yoon, Hyuna Noh, Heejin Jin, Sungyoung Lee, Soyul Han, Sung-Hee Kim, Jiseon Kim, Jung Seon Seo, Jeong Jin Kim, In Ho Park, Jooyeon Oh, Joon-Yong Bae, Gee Eun Lee, Sun-Je Woo, Sun-Min Seo, Na-Won Kim…
    Citation: Laboratory Animal Research 2022 38:17
    Content type: Research Published on:

  26. Intravital imaging via two-photon microscopy (TPM) is a useful tool for observing and delineating biological events at the cellular and molecular levels in live animals in a time-lapse manner. This imaging met...

    Authors: Da Jeong Byun, Young Min Kim and Young-Min Hyun
    Citation: Laboratory Animal Research 2022 38:16
    Content type: Review Published on:

  28. The use of animals in biomedical science remains controversial. An individual’s level of concern is generally influenced by their culture, previous or current experience with animals, and the specific animal s...

    Authors: Olatz Goñi-Balentziaga, Iván Ortega-Saez, Sergi Vila and Garikoitz Azkona
    Citation: Laboratory Animal Research 2022 38:14
    Content type: Research Published on:

  29. Retinoic acid is a major metabolite of vitamin A and exerts beneficial effects including anti-oxidant and anti-inflammatory activities in neurons. The ubiquitin–proteasome system is an important biological sys...

    Authors: Ju-Bin Kang, Murad-Ali Shah, Dong-Ju Park and Phil-Ok Koh
    Citation: Laboratory Animal Research 2022 38:13
    Content type: Research Published on:

  30. Transcranial direct current stimulation (tDCS) has been studied as a tool to stimulate the functional recovery of neurons after stroke. Although this device has recently begun to be utilized for providing neur...

    Authors: Jong-Hun Lee, Bo Hyun Jung and Ki-Yeon Yoo
    Citation: Laboratory Animal Research 2022 38:12
    Content type: Research Published on:

  31. Activating the immune system for therapeutic benefit has long been a goal in immunology, especially in cancer treatment, but the low immunogenicity of antitumor vaccines remains a limiting factor in the fight ...

    Authors: Jhonne Pedro Pedott Santana, Priscyla Daniely Marcato, Tais Nader Chrysostomo Massaro, Naiane Lima Godoy, Fernanda de Freitas Anibal and Ricardo Carneiro Borra
    Citation: Laboratory Animal Research 2022 38:11
    Content type: Research Published on:

  32. Principles of 3Rs are the backbone of today’s animal research. Applying 3Rs in practice requires proper education and training. Although this could be achieved via long-term courses ranging from several weeks ...

    Authors: Siavash Ahmadi-Noorbakhsh, Jila Sadighi, Zahra Hatami and Ehsan Shamsi Gooshki
    Citation: Laboratory Animal Research 2022 38:10
    Content type: Short Communication Published on:

  33. Non-invasive measurement of somatosensory-evoked potentials (SEP) in a large animal model is important to translational cognitive research. We sought to develop a methodology for neurophysiological recording v...

    Authors: Guillaume L. Hoareau, Angela Peters, David Hilgart, Marta Iversen, Gregory Clark, Matthew Zabriskie, Viola Rieke, Candace Floyd and Lubdha Shah
    Citation: Laboratory Animal Research 2022 38:9
    Content type: Methodology Published on:

  35. Botulinum toxin (BoNT) is a widely used therapeutic agent that blocks the excessive release of acetylcholine at the neuromuscular junction. Previously, repeated intracremasteric injections and slight overdose ...

    Authors: Risna Kanjirassery Radhakrishnan, Sowbarnika Ravichandran, Aishwarya Sukesh, Balamuthu Kadalmani and Mahesh Kandasamy
    Citation: Laboratory Animal Research 2022 38:7
    Content type: Research Published on:

  36. The common marmoset is widely used in current biomedical research for various research fields. We observed macrocytic anemia in a perinatal common marmoset with gradual weight loss and diarrhea. The objective ...

    Authors: Jong-Min Kim, Jina Kwak, Hyun-Jin Lim, Joo-Il Kim and Byeong-Cheol Kang
    Citation: Laboratory Animal Research 2022 38:6
    Content type: Case Report Published on:

  37. Zebrafish is considered an unprecedented animal model in drug discovery. A review of the literature presents highlights and elucidates the biological effects of chemical components found in Cannabis sativa. Parti...

    Authors: Ricardo Lacava Bailone, Hirla Costa Silva Fukushima, Luis Kluwe de Aguiar and Ricardo Carneiro Borra
    Citation: Laboratory Animal Research 2022 38:5
    Content type: Review Published on:

  38. Pulmonary venous aneurysm (PVA) is a rare condition characterized by aneurysmal dilatation of the pulmonary vein in humans. The diagnosis is incidental usually as there are no clinical symptoms. This case repo...

    Authors: Jong-Min Kim, Chang Gok Woo, Sa Hun Kim, Eui-Suk Jeong, Kil-Soo Kim and Byeong-Cheol Kang
    Citation: Laboratory Animal Research 2022 38:4
    Content type: Case Report Published on:

  40. Hamster is widely used as an experimental model in the study of reproductive system. However, pregnancy diagnosis and aging always have been a challenge. ultrasonography have been used in diagnosis of pregnanc...

    Authors: Mohammad Amin Keshavarz, Asghar Mogheiseh, Mohammad Saeed Ahrari-Khafi and Reza Mahboobi
    Citation: Laboratory Animal Research 2022 38:2
    Content type: Research Published on:

  41. The convertase subtilisin/kexin family 1 gene (PCSK1) has been associated in various human genetics studies with a wide spectrum of metabolic phenotypes, including early-onset obesity, hyperphagia, diabetes in...

    Authors: Aleksandra Aljakna Khan, Nakyung Kim, Ron Korstanje and Seungbum Choi
    Citation: Laboratory Animal Research 2022 38:1
    Content type: Research Published on:

  42. To determine whether the background of BALB/c substrains affects the response to anti-tumor drugs, we measured for alterations in tumor growth, histopathological structure of the tumor, and expressions of tumo...

    Authors: Jeong Eun Gong, You Jung Jin, Ji Eun Kim, Yun Ju Choi, Su Jin Lee, Kil Soo Kim, Young Suk Jung, Joon Yong Cho, Yong Lim, Hyun Gu Kang and Dae Youn Hwang
    Citation: Laboratory Animal Research 2021 37:33
    Content type: Research Published on:

  43. This study was undertaken to compare the sensitivities of mice strains during tumor induction by transcription activator-like effector nucleases (TALEN)-mediated Trp53 mutant gene. Alterations of their tumorig...

    Authors: Woo Bin Yun, Ji Eun Kim, Mi Lim Lee, Jun Young Choi, Jin Ju Park, Bo Ram Song, Byeong Cheol Kang, Ki Taek Nam, Han-Woong Lee and Dae Youn Hwang
    Citation: Laboratory Animal Research 2021 37:32
    Content type: Research Published on:

  44. The oral administration of polystyrene-microplastics (PS-MPs) causes chronic constipation of ICR mice, but there are no reports on their effects on the inflammatory response in the colon. To determine if the o...

    Authors: Yun Ju Choi, Ji Eun Kim, Su Jin Lee, Jeong Eun Gong, You Jeong Jin, Sungbaek Seo, Jae Ho Lee and Dae Youn Hwang
    Citation: Laboratory Animal Research 2021 37:31
    Content type: Research Published on:

  45. Ventilator-induced lung injury (VILI) is a serious acute injury to the lung tissue that can develop during mechanical ventilation of patients. Due to the mechanical strain of ventilation, damage can occur in t...

    Authors: Jon Petur Joelsson, Saevar Ingthorsson, Jennifer Kricker, Thorarinn Gudjonsson and Sigurbergur Karason
    Citation: Laboratory Animal Research 2021 37:30
    Content type: Review Published on:

  46. Telemetry is a wireless implanted device that measures biological signals in conscious animals and usually requires surgery for its removal when the study is finished. After removing the device, the animals ar...

    Authors: Doo-Wan Cho, Hyoung-Yun Han, Mi-Jin Yang, Dong Ho Woo, Su-Cheol Han and Young-Su Yang
    Citation: Laboratory Animal Research 2021 37:29
    Content type: Case Report Published on:

  47. Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease. Despite alveolar epithelial cells is crucial role in lung, its contribution and the associated biomarker remain unkno...

    Authors: Hyosin Baek, Soojin Jang, Jaehyun Park, Jimin Jang, Jooyeon Lee, Seok-Ho Hong, Woo Jin Kim, Sung-Min Park and Se-Ran Yang
    Citation: Laboratory Animal Research 2021 37:28
    Content type: Research Published on:

  48. Recently a screen from a library of 1.8 million compounds identified in vitro a potent activity of the 2-aminobenzimidazoles series against Leishmania infantum, the etiological agent responsible by over 20.000 de...

    Authors: Hirla Costa Silva Fukushima, Ricardo Lacava Bailone, Tatiana Corrêa, Helena Janke, Luís Kluwe De Aguiar, Princia Grejo Setti and Ricardo Carneiro Borra
    Citation: Laboratory Animal Research 2021 37:27
    Content type: Research Published on:

  49. Since its debut in the biomedical research fields in 1981, zebrafish have been used as a vertebrate model organism in more than 40,000 biomedical research studies. Especially useful are zebrafish lines express...

    Authors: Chong Pyo Choe, Seok-Yong Choi, Yun Kee, Min Jung Kim, Seok-Hyung Kim, Yoonsung Lee, Hae-Chul Park and Hyunju Ro
    Citation: Laboratory Animal Research 2021 37:26
    Content type: Review Published on:

  50. Electrocardiogram (ECG) is a non-invasive valuable diagnostic tool that is used in clinics for investigation and monitoring of heart electrical rhythm/conduction, ischemia/injury of heart, electrolyte disturba...

    Authors: Siyavash Joukar
    Citation: Laboratory Animal Research 2021 37:25
    Content type: Review Published on:
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  • Laboratory Animal Research is the official journal of the Korean Association for Laboratory Animal Science. KALAS was established in 1985 in order to discuss the knowledge of the experiment, and promote the science and technology in laboratory animal sciences.

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