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  1. Cognitive impairment responses are important research topics in the study of degenerative brain diseases as well as in understanding of human mental activities. To compare response to scopolamine (SPL)-induced...

    Authors: Woo Bin Yoon, Hyeon Jun Choi, Ji Eun Kim, Ji Won Park, Mi Ju Kang, Su Ji Bae, Young Ju Lee, You Sang Choi, Kil Soo Kim, Young-Suk Jung, Joon-Yong Cho, Dae Youn Hwang and Hyun Keun Song

    Citation: Laboratory Animal Research 2018 34:3404317

    Content type: OriginalPaper

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  2. Placenta specific 8 (PLAC8, also known as ONZIN) is a multi-functional protein that is highly expressed in the intestine, lung, spleen, and innate immune cells, and is involved in various diseases, including c...

    Authors: HyunJeong Lee, Joo-Il Kim, Jin-Sung Park, Jae-il Roh, Jaehoon Lee, Byeong-Cheol Kang and Han-Woong Lee

    Citation: Laboratory Animal Research 2018 34:3404279

    Content type: OriginalPaper

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  3. This study was conducted to compare the anesthetic effects of 2,2,2-tribromoethanol (TBE, Avertin®) in ICR mice obtained from three different sources. TBE (2.5%) was intraperitoneally injected at three doses: ...

    Authors: Mi Ree Lee, Hye Rin Suh, Myeong Whan Kim, Joon Young Cho, Hyun Keun Song, Young Suk Jung, Dae Youn Hwang and Kil Soo Kim

    Citation: Laboratory Animal Research 2018 34:3404270

    Content type: OriginalPaper

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  4. Bacopa monnieri is a medicinal plant with a long history of use in Ayurveda, especially in the treatment of poor memory and cognitive deficits. In the present study, we hypothesized that Bacopa monnieri extract (...

    Authors: Hyun Jung Kwon, Hyo Young Jung, Kyu Ri Hahn, Woosuk Kim, Jong Whi Kim, Dae Young Yoo, Yeo Sung Yoon, In Koo Hwang and Dae Won Kim

    Citation: Laboratory Animal Research 2018 34:3404239

    Content type: OriginalPaper

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  5. Animal models have been used to elucidate the pathophysiology of varying diseases and to provide insight into potential targets for therapeutic intervention. Although alternatives to animal testing have been p...

    Authors: Seunghyun Lee, Jae-Hwan Kwak, Sou Hyun Kim, Jieun Yun, Joon-Yong Cho, Kilsoo Kim, Daeyeon Hwang and Young-Suk Jung

    Citation: Laboratory Animal Research 2018 34:3404232

    Content type: OriginalPaper

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  6. Hyperglycemia is one of the major risk factors for stroke. Hyperglycemia can lead to a more extensive infarct volume, aggravate neuronal damage after cerebral ischemia. α-Synuclein is especially abundant in ne...

    Authors: Ju-Bin Kang, Dong-Kyun Kim, Dong-Ju Park, Murad-Ali Shah, Myeong-Ok Kim, Eun-Jung Jung, Han-Shin Lee and Phil-Ok Koh

    Citation: Laboratory Animal Research 2018 34:3404195

    Content type: OriginalPaper

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  7. In this study, we observed chronological changes in the immunoreactivity and expression level of myelin basic protein (MBP), one of the most abundant proteins in the central nervous system, in the hippocampus ...

    Authors: Sung Min Nam, Hyun Jung Kwon, Woosuk Kim, Jong Whi Kim, Kyu Ri Hahn, Hyo Young Jung, Dae Won Kim, Dae Young Yoo, Je Kyung Seong, In Koo Hwang and Yeo Sung Yoon

    Citation: Laboratory Animal Research 2018 34:3404176

    Content type: OriginalPaper

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  8. Recombination activating gene-2 (RAG-2) plays a crucial role in the development of lymphocytes by mediating recombination of T cell receptors and immunoglobulins, and loss of RAG-2 causes severe combined immunode...

    Authors: Joo-Il Kim, Jin-Sung Park, Hanna Kim, Soo-Kyung Ryu, Jina Kwak, Euna Kwon, Jun-Won Yun, Ki-Taek Nam, Han-Woong Lee and Byeong-Cheol Kang

    Citation: Laboratory Animal Research 2018 34:3404166

    Content type: OriginalPaper

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  9. Breast cancer remains the second leading cause of cancer death among woman, worldwide, despite advances in identifying novel targeted therapies and the development of treating strategies. Classification of cli...

    Authors: Mi Kyung Park, Chang Hoon Lee and Ho Lee

    Citation: Laboratory Animal Research 2018 34:3404160

    Content type: Review

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  10. Genetically engineered mouse models are commonly preferred for studying the human disease due to genetic and pathophysiological similarities between mice and humans. In particular, Cre-loxP system is widely used ...

    Authors: Hyeonhui Kim, Minki Kim, Sun-Kyoung Im and Sungsoon Fang

    Citation: Laboratory Animal Research 2018 34:3404147

    Content type: Review

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  11. In the Materials and Methods section, material supply source is incorrectly cited and has been changed upon request of authors. In Acknowledgments, following paragraph would be added by authors’ request.

    Authors: Song-Hee Han, Sung-June Kim, Young Won Yun, Sang Yoon Nam, Hu-Jang Lee and Beom-Jun Lee

    Citation: Laboratory Animal Research 2018 34:3403132

    Content type: Erratum

    Published on:

    The original article that this is related to.

  12. Serum levels of the pro-inflammatory apolipoprotein CIII (apoCIII) are increased in type-1 diabetic (T1D) patients and when β-cells are exposed to apoCIII they undergo apoptosis, which can be prevented by an a...

    Authors: Karin Åvall, Per-Olof Berggren and Lisa Juntti-Berggren

    Citation: Laboratory Animal Research 2018 34:3403126

    Content type: OriginalPaper

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  13. To evaluate the carcinogenicity of p27 knockout (KO) mice with RNA-guided endonuclease (RGENs)-mediated p27 mutant exon I gene (IΔ), alterations in the carcinogenic phenotypes including tumor spectrum, tumor s...

    Authors: Jun Young Choi, Woo Bin Yun, Ji Eun Kim, Mi Rim Lee, Jin Ju Park, Bo Ram Song, Hye Ryeong Kim, Ji Won Park, Mi Ju Kang, Byeong Cheol Kang, Han-Woong Lee and Dae Youn Hwang

    Citation: Laboratory Animal Research 2018 34:3403118

    Content type: OriginalPaper

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  14. Benign prostate hyperplasia (BPH) is a male reproductive disease that has gained increasing importance in recent years. The present study investigated whether Pycnogenol® (PYC), a standardized French maritime ...

    Authors: Je-Won Ko, So-Won Park, Na-Rae Shin, Woong-Il Kim, Jong-Choon Kim, In-Sik Shin and Dong-Ho Shin

    Citation: Laboratory Animal Research 2018 34:3403111

    Content type: OriginalPaper

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  15. The butanol extract of Asparagus cochinchinensis roots fermented with Weissella cibaria (BAfW) significantly suppressed the inflammatory response induced by lipopolysaccharide (LPS) treatment in RAW264.7 cells. T...

    Authors: Jun Young Choi, Ji Won Park, Ji Eun Kim, Jin Ju Park, Mi Rim Lee, Bo Ram Song, Mi Ju Kang and Dae Youn Hwang

    Citation: Laboratory Animal Research 2018 34:3403101

    Content type: OriginalPaper

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  16. Water extract of guibi-tang (GB), a traditional Chinese, Japanese, and Korean herbal medicine, is used to treat memory impairment, insomnia, and peptic ulcers. The aim of this study was to investigate the prot...

    Authors: Na-Rae Shin, Tae-Yang Jung, Chang-Seob Seo, So-Won Park, Je-Won Ko, Jong-Choon Kim and In-Sik Shin

    Citation: Laboratory Animal Research 2018 34:3403092

    Content type: OriginalPaper

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  17. Hepatitis B virus (HBV) infection remains a major global health problem; indeed, there are 250 million carriers worldwide. The host range of HBV is narrow; therefore, few primates are susceptible to HBV infect...

    Authors: Jeong-Ryul Hwang and Sung-Gyoo Park

    Citation: Laboratory Animal Research 2018 34:3403085

    Content type: Review

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  18. The elimination half-lives of in Interleukin-6 (IL-6) and cytokine-induced neutrophil chemoattractant-1 (CINC-1) in rats after inflammatory stimulation were investigated. Five male Sprague-Dawley rats were use...

    Authors: Takashi Kuribayashi

    Citation: Laboratory Animal Research 2018 34:3402080

    Content type: Case Report

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  19. Allium hookeri is widely consumed plant as a vegetable and herbal medicine in southeastern Asia. Allium hookeri has been reported antioxidant, improvement of bone health and antidiabetic effects. In the present s...

    Authors: Hyun-A Lee, Sunhwa Hong, Ji-Hyun Yoo, Yungho Chung and Okjin Kim

    Citation: Laboratory Animal Research 2018 34:3402075

    Content type: OriginalPaper

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  20. The purpose of the study was to investigate the effects of lipid-coated ZnO (LCZ) and the level of LCZ compared with ordinary zinc oxide (ZnO) on antioxidant defense system in the intestine and liver of piglet...

    Authors: Ha-Na Kim, Dong-Gyung Jeon, Chul Young Lee and In-Surk Jang

    Citation: Laboratory Animal Research 2018 34:3402065

    Content type: OriginalPaper

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  21. In the present study, we compared the cell-specific expression and changes protein levels in the glucose transporters (GLUTs) 1 and 3, the major GLUTs in the mouse and gerbil brains using immuno-histochemistry...

    Authors: Kwon Young Lee, Dae Young Yoo, Hyo Young Jung, Loktam Baek, Hangyul Lee, Hyun Jung Kwon, Jin Young Chung, Seok Hoon Kang, Dae Won Kim, In Koo Hwang and Jung Hoon Choi

    Citation: Laboratory Animal Research 2018 34:3402058

    Content type: OriginalPaper

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  22. Hangover is characterized by a number of unpleasant physical and mental symptoms that occur after heavy alcohol drinking. In addition, consistently excessive alcohol intake is considered as a major reason caus...

    Authors: Jae Young Yu, Hanh Thuy Nguyen, Chul Soon Yong, Hyoung Geun Park, Joon Ho Jun and Jong Oh Kim

    Citation: Laboratory Animal Research 2018 34:3402049

    Content type: OriginalPaper

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  23. In this article, So-Young Park is inadvertently omitted from the listed author names. In the Acknowledgement section, funding source is incorrectly cited and has been changed upon request of authors.

    Authors: Young-Hwan Ban, Yeseul Cha, Jieun Choi, Eun Suk An, Ji Young Lee, Nu Ry Han, Da Woom Seo, Gooyoung Jung, Da-Hye Jeong, Man Hee Rhee, Ehn-Kyoung Choi and Yun-Bae Kim

    Citation: Laboratory Animal Research 2018 34:3101048

    Content type: Erratum

    Published on:

    The original article was published in Laboratory Animal Research 2017 33:3302105

  24. Anti-coccidial effects of the fruits of Tribulus terrestris (Tribuli fructus) ethanol extract (TTE) were studied with animal experiment following per oral administration with Eimeria (E.) tenella. This experiment...

    Authors: Sunhwa Hong, Mi-Na Moon, Eun-Kyung Im, Jum-Soon Won, Ji-Hyun Yoo and Okjin Kim

    Citation: Laboratory Animal Research 2018 34:3101044

    Content type: Letter

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  25. This study was performed to investigate the effect of a concentrate of fermented wild ginseng root culture (HLJC0701) on memory improvement in the scopolamine (SPL)-induced memory-deficient mouse model. Eight-...

    Authors: Song-Hee Han, Sung-June Kim, Young Won Yun, Sang Yoon Nam, Hu-Jang Lee and Beom-Jun Lee

    Citation: Laboratory Animal Research 2018 34:3101037

    Content type: OriginalPaper

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  26. This study investigated the anti-cancer potential of a near-infrared fluorescence (NIRF) molecule conjugated with Cetuximab (Cetuximab-NIRF) in six-week-old female BALB/c athymic (nu+/nu+) nude mice. A431 cell...

    Authors: Ji Young Yun, Byung-Hwa Hyun, Sang Yoon Nam, Young Won Yun, Hu-Jang Lee and Beom-Jun Lee

    Citation: Laboratory Animal Research 2018 34:3101030

    Content type: OriginalPaper

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  27. C57BL/6N mice are inbred strains widely used in biomedical research. Hence, a large amount of basic data has been accumulated. However, in the field of histopathology, spontaneous data for relatively younger m...

    Authors: Do-Yong Park, Byoung-Seok Lee, Woo-Jin Kim, Wan-Jung Im, Ji-Seok Han, Heejin Park, Mi-Jin Yang, Jae-Woo Cho, Da Hee Kim, Su-Cheol Han, Yong-Bum Kim and Hwa-Young Son

    Citation: Laboratory Animal Research 2018 34:3101020

    Content type: OriginalPaper

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  28. The aim of this study is to evaluate the reporting quality of animal experiments in Korea using the Animals in Research: Reporting In Vivo Experiments (ARRIVE) guideline developed in 2010 to overcome the reproduc...

    Authors: Mi-Hyun Nam, Myung-Sun Chun, Je-Kyung Seong and Hoon-Gi Kim

    Citation: Laboratory Animal Research 2018 34:3101011

    Content type: OriginalPaper

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  29. Chronic obstructive pulmonary disease (COPD) was the 3rd leading cause of death in 2012 worldwide. It is particularly severe in the elderly, who are at risk of death by coughing, mucous hypersecretion, and finall...

    Authors: Soon-Young Lee, Jin-Ho Cho, Seung Sik Cho, Chun-Sik Bae, Gye-Yeop Kim and Dae-Hun Park

    Citation: Laboratory Animal Research 2018 34:3101001

    Content type: OriginalPaper

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  30. Quercetin, a natural flavonoid, copiously exists in vegetable, fruits and tea. Quercetin is beneficial to neurodegenerative disorders via its strong anti-oxidant and anti-inflammatory activities. γ-Enolase is ...

    Authors: Seong-Jun Jeon, Myeong-Ok Kim, Fawad Ali-Shah and Phil-Ok Koh

    Citation: Laboratory Animal Research 2018 33:3304308

    Content type: OriginalPaper

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  31. A correlation between endoplasmic reticulum (ER) stress and laxative effects was first reported in a constipation model treated with an aqueous extract of Liriope platyphylla (AEtLP) roots. To investigate the cor...

    Authors: Ji Eun Kim, Bo Ram Song, Woo Bin Yun, Jun Young Choi, Jin Ju Park, Mi Rim Lee and Dae Youn Hwang

    Citation: Laboratory Animal Research 2018 33:3304298

    Content type: OriginalPaper

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  32. Thread-embedding therapy has been widely applied for cosmetic purposes such as wrinkle reduction and skin tightening. Particularly, gold thread was reported to support connective tissue regeneration, but, its ...

    Authors: Jong-Hwan Kim, Eun-Young Cho, Euna Kwon, Woo-Ho Kim, Jin-Sung Park, Yong-Soon Lee, Jun-Won Yun and Byeong-Cheol Kang

    Citation: Laboratory Animal Research 2018 33:3304291

    Content type: OriginalPaper

    Published on:

  33. One of the authors’ names was misprinted. The author list should be corrected as follows.

    Authors: Woo Bin Yun, Hye Ryeong Kim, Ji Eun Kim, Jun Young Choi, Mi Rim Lee, Jin Ju Park, Bo Ram Song, Young Suk Jung, Hyun Keun Song, Joon Young Cho, Kil Soo Kim and Dae Youn Hwang

    Citation: Laboratory Animal Research 2017 33:3304321

    Content type: Erratum

    Published on:

    The original article was published in Laboratory Animal Research 2017 33:3302179

  34. One of the authors’ names was misprinted. The author list should be corrected as follows.

    Authors: Ji Eun Kim, Jung Hoon Nam, Joon Young Cho, Kil Soo Kim and Dae Youn Hwang

    Citation: Laboratory Animal Research 2017 33:3304320

    Content type: Erratum

    Published on:

    The original article was published in Laboratory Animal Research 2017 33:3302171

  35. One of the authors’ names was misprinted. The author list should be corrected as follows.

    Authors: Sou Hyun Kim, Keuk-Jun Kim, Joung-Hee Kim, Jae-Hwan Kwak, HyunKeun Song, Joon Young Cho, Dae Youn Hwang, Kil Soo Kim and Young-Suk Jung

    Citation: Laboratory Animal Research 2017 33:3304319

    Content type: Erratum

    Published on:

    The original article was published in Laboratory Animal Research 2017 33:3302165

  36. One of the authors’ names was misprinted. The author list should be corrected as follows.

    Authors: Sou Hyun Kim, Yong Lim, Ju Bin Park, Jae-Hwan Kwak, Keuk-Jun Kim, Joung-Hee Kim, HyunKeun Song, Joon Young Cho, Dae Youn Hwang, Kil Soo Kim and Young-Suk Jung

    Citation: Laboratory Animal Research 2017 33:3304318

    Content type: Erratum

    Published on:

    The original article was published in Laboratory Animal Research 2017 33:3302157

  37. One of the authors’ names was misprinted. The author list should be corrected as follows.

    Authors: Dong-Ju Hwang, Hyun-Keun Song, Kil-Soo Kim, Young-Suk Jung, Dae-Youn Hwang and Joon Young Cho

    Citation: Laboratory Animal Research 2017 33:3304317

    Content type: Erratum

    Published on:

    The original article was published in Laboratory Animal Research 2017 33:3302140

  38. One of the authors’ names was misprinted. The author list should be corrected as follows.

    Authors: Hye Ryeong Kim, Jun Young Choi, Kil Soo Kim, Young-Suk Jung, Joon Young Cho, Dae Youn Hwang and Hyun Keun Song

    Citation: Laboratory Animal Research 2017 33:3304316

    Content type: Erratum

    Published on:

    The original article was published in Laboratory Animal Research 2017 33:3302132

  39. One of the authors’ names was misprinted. The author list should be corrected as follows.

    Authors: Jun Young Choi, Hye Ryeong Kim, Kil Soo Kim, Young-Suk Jung, Joon Young Cho, Dae Youn Hwang and Hyun Keun Song

    Citation: Laboratory Animal Research 2017 33:3304315

    Content type: Erratum

    Published on:

    The original article was published in Laboratory Animal Research 2017 33:3302124

  40. In the present study, we examined the effects of Dendropanax morbifera Léveille leaf extract (DML) on dgalactose-induced morphological changes in microglia and cytokines, including pro-inflammatory cytokines (int...

    Authors: Kwon Young Lee, Hyo Young Jung, Dae Young Yoo, Woosuk Kim, Jong Whi Kim, Hyun Jung Kwon, Dae Won Kim, Yeo Sung Yoon, In Koo Hwang and Jung Hoon Choi

    Citation: Laboratory Animal Research 2017 33:3304283

    Content type: OriginalPaper

    Published on:

  41. This paper reports a case of super pregnancy in a BALB/c mouse pregnant with 30 pups following induction of superovulation using a PMSG-hCG protocol. Superovulation was induced in 10 mice by injecting 5 IU PMS...

    Authors: Hanieh Vaseghi, Asghar Mogheiseh, Masood Sepehrimanesh, Mojtaba Kafi and Mohammad Hossein Nooranizadeh

    Citation: Laboratory Animal Research 2017 33:3303280

    Content type: Case Report

    Published on:

  42. Successful male germ cell transplantation requires depletion of the host germ cells to allow efficient colonization of the donor spermatogonial stem cells. Although a sterilizing drug, busulfan, is commonly us...

    Authors: Tai-Young Hur, Seung-Hoon Lee, Sun-A Ock, Hyuk Song, Hyun-Jung Park, Ran Lee, Si-Heung Sung, Hyunjhung Jhun and Won-Young Lee

    Citation: Laboratory Animal Research 2017 33:3303264

    Content type: OriginalPaper

    Published on:

  43. Recently, worldwide dietary reference intakes have been considered an important guideline for public health. Some governments and the World Health Organization (WHO) provide guidelines concerning dietary intak...

    Authors: So-Hyeon Bok, Seung Sik Cho, Chun-Sik Bae, Dae-Hun Park and Kyung-Mok Park

    Citation: Laboratory Animal Research 2017 33:3303251

    Content type: OriginalPaper

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  44. Myelin degeneration is one of the characteristics of aging and degenerative diseases. This study investigated age-related alterations in expression of myelin basic protein (MBP) in the hippocampal subregions (...

    Authors: Ji Hyeon Ahn, Tae-Kyeong Lee, Joon Ha Park, Jeong Hwi Cho, In Hye Kim, Jae Chul Lee, Seongkweon Hong, Yong Hwan Jeon, Il Jun Kang, Young Joo Lee, Moo-Ho Won and Choong-Hyun Lee

    Citation: Laboratory Animal Research 2017 33:3303237

    Content type: OriginalPaper

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  45. Among three representative species of Angelica found in Asian countries, including Korea, China, and Japan, Angelica acutiloba (AA) has been used as traditional herbal medicine with antitumor, antiinflammatory, a...

    Authors: Jun-Won Yun, Yun-Soon Kim, Euna Kwon, Seung-Hyun Kim, Ji-Ran You, Hyeon Hoe Kim, Jeong-Hwan Che and Byeong-Cheol Kang

    Citation: Laboratory Animal Research 2017 33:3303231

    Content type: OriginalPaper

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  46. This study aims to evaluate early changes in retinal structure and BMP2 expression in the retina and crystalline lens by comparing streptozotocin-induced diabetic pigs and normal control group pigs.

    Authors: Jae Seung Jeong, Woon-Kyu Lee, Yeon Sung Moon and Na Rae Kim

    Citation: Laboratory Animal Research 2017 33:3303216

    Content type: OriginalPaper

    Published on:

  47. Pet turtles are well-known to harbor an array of bacterial pathogens which can cause zoonotic infections in humans as well as opportunistic infections in the turtles itself. Essential oils are the natural plan...

    Authors: Sabrina Hossain, Honghoi Heo, B. C. J. De Silva, S. H. M. P. Wimalasena, H. N. K. S. Pathirana and Gang-Joon Heo

    Citation: Laboratory Animal Research 2017 33:3303195

    Content type: OriginalPaper

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Affiliated with


  • Laboratory Animal Research is the official journal of the Korean Association for Laboratory Animal Science. KALAS was established in 1985 in order to discuss the knowledge of the experiment, and promote the science and technology in laboratory animal sciences.

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