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  1. Immune profiling has become an important tool for identifying predictive, prognostic and response biomarkers for immune checkpoint inhibitors from tumor microenvironment (TME). We aimed to build a multiplex im...

    Authors: Jie Zhai, Auriole Tamegnon, Mei Jiang, Renganayaki Krishna Pandurengan and Edwin Roger Parra
    Citation: Laboratory Animal Research 2024 40:24
  2. The aim of the study was to develop a technique for quantitative determination of rat urine metabolites by HPLC–MS/MS, which can be used to search for biomarkers of acute intoxication with organophosphates (OPs).

    Authors: Michael A. Leninsky, Vladislav E. Sobolev, Margarita O. Sokolova, Natalya G. Voitenko and Nikita V. Skvortsov
    Citation: Laboratory Animal Research 2024 40:23
  3. Toxicity by pesticide has become a global health issue and leaves a harmful impact on human health via various ways. The people exposed to pesticides in the rural population get affected by the harmful effects...

    Authors: Priya, Arun Kumar, Mohammad Ali, Abhinav Srivastava, Ranjit Kumar and Ashok Kumar Ghosh
    Citation: Laboratory Animal Research 2024 40:22
  4. Thyroid hormones (THs) regulate growth, development and function of different tissues. Hypothyroidism is a common clinical disorder characterized by deficiency in THs and adversely affects the development and ...

    Authors: Hadeel M. Osama, Sally M. Khadrawy, EL-Shaymaa EL-Nahass, Sarah I. Othman and Hanaa M. Mohamed
    Citation: Laboratory Animal Research 2024 40:19
  5. Community-acquired respiratory infection is the commonest cause of sepsis presenting to emergency departments. Yet current experimental animal models simulate peritoneal sepsis with intraperitoneal (I.P.) injecti...

    Authors: Yaqing Jiao, Cindy S. W. Tong, Lingyun Zhao, Yilin Zhang, John M. Nicholls and Timothy H. Rainer
    Citation: Laboratory Animal Research 2024 40:18
  6. Scientific progress heavily relies on rigorous research, adherence to scientific standards, and transparent reporting. Animal models play a crucial role in advancing biomedical research, especially in the fiel...

    Authors: Parham Soufizadeh, Vahid Mansouri and Naser Ahmadbeigi
    Citation: Laboratory Animal Research 2024 40:17
  7. Therapeutic interventions for diabetes are most effective when administered in the newly onset phase, yet determining the exact onset moment can be elusive in practice. Spontaneous autoimmune diabetes among NO...

    Authors: Chia-Chi Liao, Chia-Chun Hsieh, Wei-Chung Shia, Min-Yuan Chou, Chuan-Chuan Huang, Jhih-Hong Lin, Shu-Hsien Lee and Hsiang-Hsuan Sung
    Citation: Laboratory Animal Research 2024 40:16
  8. Mercury chloride (HgCl2) damages tissues it comes in contact with in sufficient concentration. This study evaluated the protective effects of n-butanol fraction of Phoenix dactylifera (BFPD) on mercury-triggered ...

    Authors: Musa Garba Abubakar, AN Agbon, SA Musa, WO Hamman and SB Oladele
    Citation: Laboratory Animal Research 2024 40:15
  9. Gastrodia elata Blume (GEB), a traditional medicinal herb, has been reported to have pharmacological effect including protection against liver, neuron and kidney toxicity. However, explanation of its underlying m...

    Authors: Yeon Su Lee, Yu Rim Park, Hyo Bin Lee, Hye Joon Park, Ha Eun Lee, Geon A Kim, Sang-Hoon Kim and Jae-Ho Shin
    Citation: Laboratory Animal Research 2024 40:14
  10. Atopic dermatitis (AD) is a biphasic type of skin inflammation characterized by a predominance of type-2 (TH2) and type-1 (TH1) helper T cell-biased immune responses at the acute and persistent chronic phases, re...

    Authors: Manju Acharya, Ravi Gautam, SuJeong Yang, JiHun Jo, Anju Maharjan, DaEun Lee, Narayan Prasad Ghimire, ByeongSun Min, ChangYul Kim, HyoungAh Kim and Yong Heo
    Citation: Laboratory Animal Research 2024 40:13
  11. Although radiotherapy is commonly used to treat head and neck cancer, it may lead to radiation-associated dysphagia (RAD). There are various causes of RAD, however, the mechanism has not yet been fully identif...

    Authors: Shuntaro Soejima, Chia-Hsien Wu, Haruna Matsuse, Mariko Terakado, Shinji Okano, Tsuyoshi Inoue and Yoshihiko Kumai
    Citation: Laboratory Animal Research 2024 40:12
  12. The ferret (Mustela putorius furo) is a small domesticated species of the family Mustelidae within the order Carnivora. The present article reviews and discusses the current state of knowledge about housing, care...

    Authors: Ravindran Kumar Pramod, Pravin Kumar Atul, Mamta Pandey, S. Anbazhagan, Suhas T. Mhaske and R. Barathidasan
    Citation: Laboratory Animal Research 2024 40:10
  13. Alzheimer's disease (AD), the most common form of progressive dementia in the elderly, is a chronic neurological disorder that decreases cognitive ability. Although the underlying cause of AD is yet unknown, o...

    Authors: Swati Pant, Mohan Gupta, Tulika Anthwal, Monika Chauhan and Sumitra Nain
    Citation: Laboratory Animal Research 2024 40:9
  14. Ischemic stroke is a serious neurological disorder caused by blockages in cerebral artery. Protein phosphatase 2A (PP2A) is a phosphatase that performs a critical role in cell signaling and growth. PP2A subuni...

    Authors: Ju-Bin Kang, Hyun-Kyoung Son, Dong-Ju Park, Yeung-Bae Jin and Phil-Ok Koh
    Citation: Laboratory Animal Research 2024 40:8
  15. Wistar rats are extensively used as the model for assessing toxicity and efficacy in preclinical research. Hematological and biochemical laboratory data are essential for evaluating specific variations in the ...

    Authors: Suresh Patel, Satish Patel, Ashvin Kotadiya, Samir Patel, Bhavesh Shrimali, Nikita Joshi, Tushar Patel, Harshida Trivedi, Jitendra Patel, Amit Joharapurkar and Mukul Jain
    Citation: Laboratory Animal Research 2024 40:7
  16. The effects of housing conditions on animal physiology, behavior or stress are still debated. The aim of this study was to investigate the effects of three different housing systems, individually ventilated ca...

    Authors: İsmail Abidin, Hatice Keser, Elif Şahin, Hilal Öztürk, Harun Başoğlu, Ahmet Alver and Selcen Aydin-Abidin
    Citation: Laboratory Animal Research 2024 40:6
  17. Type 2 diabetes mellitus (T2DM) is a metabolic disorder affecting many organs, including the testis. Naringin from orange peel extract (OPE) is a flavanone with fertility-enhancing properties. Hence, this stud...

    Authors: Kazeem Bidemi Okesina, Adeyemi Fatai Odetayo, Wale Johnson Adeyemi, Ayodeji Johnson Ajibare, Akeem Ayodeji Okesina and Luqman Aribidesi Olayaki
    Citation: Laboratory Animal Research 2024 40:5
  18. Phytoestrogens, such as isoflavones, are known for their capacity to simulate various physiological impacts of estrogen in the human body. Our research evaluated the effects of isoflavone-enriched soybean leav...

    Authors: Dae Young Yoo, Cheng-liang Xie, Joo Yeon Jeong, Ki Hun Park, Sang Soo Kang and Dong Hoon Lee
    Citation: Laboratory Animal Research 2024 40:4
  19. High blood glucose levels in diabetes lead to vascular inflammation which accelerates atherosclerosis. Herein, Morin was orally administered in male Wistar rats, at the dose of 40 mg/kg for 28 days, and on the...

    Authors: Vipin Kumar Verma, Salma Malik, Ekta Mutneja, Anil Kumar Sahu, Vaishali Prajapati, Prashant Mishra, Jagriti Bhatia and Dharamveer Singh Arya
    Citation: Laboratory Animal Research 2024 40:3
  20. Pterospermum rubiginosum has been traditionally used by the tribal inhabitants of Southern India for treating bone fractures and as a local anti-inflammatory agent; however, experimental evidence to support this ...

    Authors: Rajamohanan Jalaja Anish, Aswathy Nair, V. Saraswathy, Velappan Nair S. Kalpana and Rajendran L. Shyma
    Citation: Laboratory Animal Research 2024 40:2
  21. Methamphetamine (MA) is a highly abused psychostimulant across all age groups including pregnant women. Because developing brain is vulnerable by the action of drugs, or other noxious stimuli, the aim of our s...

    Authors: Barbora Čechová, Jana Jurčovičová, Ivana Petríková, Šimon Vaculín, Štěpán Šandera and Romana Šlamberová
    Citation: Laboratory Animal Research 2024 40:1
  22. Sex difference has shown in the arthritis diseases in human population and animal models. We investigate how the sex and symmetry vary among mouse models with different genomic backgrounds. Disease data of sex...

    Authors: Wei Dong, Cheng Tian, Z. Galvin Li, David Brand, Yanhong Cao, Xiaoyun Liu, Jiamin Ma, Andy Chai, Linda K. Myers, Jian Yan, Karen Hasty, John Stuart, Yan Jiao, Weikuan Gu and Xiaojun Cai
    Citation: Laboratory Animal Research 2023 39:35
  23. This study aimed to establish an image evaluation grading criteria for experimental stifle joint osteoarthritis (OA) in anterior cruciate ligament transection induced OA beagle dog models. The severity of OA w...

    Authors: Beomseok Rhee, Changfan Jin, Seo-Hyun Shin, Hojung Choi, Youngwon Lee and Sokho Kim
    Citation: Laboratory Animal Research 2023 39:34
  24. Alzheimer’s disease (AD) is a multifactorial, rapidly progressing neurodegenerative disorder. As the exact cause of the disease is still unclear, the drug development is very challenging. This review encompass...

    Authors: Rishika Dhapola, Sneha Kumari, Prajjwal Sharma and Dibbanti HariKrishnaReddy
    Citation: Laboratory Animal Research 2023 39:33
  25. Unlike conventional T cells, innate and virtual-memory CD8 T cells in naïve mice acquire their memory phenotypes and functions in the absence of antigenic encounters in a cytokine-dependent manner. The relevan...

    Authors: Hi Jung Park, Eun Ah Choi, Sung Min Choi, Young-Ki Choi, Jae Il Lee and Kyeong Cheon Jung
    Citation: Laboratory Animal Research 2023 39:32
  26. Sensorineural hearing loss (SNHL), caused by pathology in the cochlea, is the most common type of hearing loss in humans. It is generally irreversible with very few effective pharmacological treatments availab...

    Authors: Po-Yi Lue, Mark H. Oliver, Michel Neeff, Peter R. Thorne and Haruna Suzuki-Kerr
    Citation: Laboratory Animal Research 2023 39:31
  27. The gut–brain axis (GBA) in Parkinson's disease (PD) has only been investigated in limited mice models despite dysbiosis of the gut microbiota being considered one of the major treatment targets for neurodegen...

    Authors: Ji Eun Kim, Ki Chun Kwon, You Jeong Jin, Ayun Seol, Hee Jin Song, Yu Jeong Roh, Tae Ryeol Kim, Eun Seo Park, Gi Ho Park, Ji Won Park, Young Suk Jung, Joon Yong Cho and Dae Youn Hwang
    Citation: Laboratory Animal Research 2023 39:30
  28. We aimed to examine the accompanying and solo impacts of conditioned medium of human adipose-derived stem cells (h-ASC-COM) and photobiomodulation (PBM) on the maturation stage of an ischemic infected delayed-...

    Authors: Kaysan Sohrabi, Houssein Ahmadi, Abdollah Amini, Behnaz Ahrabi, Atarodalsadat Mostafavinia, Hamidreza Omidi, Mansooreh Mirzaei, Fatemeh Fadaei Fathabady, Mohammadjavad Fridoni, Maryam Rahmannia, Sufan Chien and Mohammad Bayat
    Citation: Laboratory Animal Research 2023 39:29
  29. Feline mammary carcinoma (FMC) is one of the most prevalent malignancies of female cats. FMC is highly metastatic and thus leads to poor disease outcomes. Among all metastases, liver metastasis occurs in about...

    Authors: Yi-Chih Chang, Hao-Ping Liu, Hsiao-Li Chuang, Jiunn-Wang Liao, Pei-Ling Kao, Hsun-Lung Chan, Ter-Hsin Chen and Yu-Chih Wang
    Citation: Laboratory Animal Research 2023 39:27
  30. Influenza A viruses (IAVs) have long posed a threat to humans, occasionally causing significant morbidity and mortality. The initial immune response is triggered by infected epithelial cells, alveolar macropha...

    Authors: Eun Ah Choi, Hi Jung Park, Sung Min Choi, Jae Il Lee and Kyeong Cheon Jung
    Citation: Laboratory Animal Research 2023 39:26
  31. Chronic skin wounds are a common complication of many diseases such as diabetes. Various traditional methods for assessing skin wound closure are used in animal studies, including wound tracing, calliper measu...

    Authors: Coco X. Huang, Elisha Siwan, Sarah L. Fox, Matilda Longfield, Stephen M. Twigg and Danqing Min
    Citation: Laboratory Animal Research 2023 39:25
  32. The importance of animal welfare is being recognized worldwide. Recently, the increasing demand for enhanced laboratory animal welfare has led to clinically featured transformations of animal research institut...

    Authors: Gwang-Hoon Lee, Woori Jo, Joon-Suk Park, Tae-Ku Kang, Soo-Eun Sung, Taeho Oh and KilSoo Kim
    Citation: Laboratory Animal Research 2023 39:24
  33. To evaluate the chemosensitivity to doxorubicin (DOX) in two primary cells derived from a tumor of FVB/N-Trp53tm1Hw1 knockout (KO) mice with TALEN-mediated Trp53 mutant gene, we evaluated the cell survivability, ...

    Authors: Woobin Yun, Ji Eun Kim, You Jeong Jin, Yu Jeong Roh, Hee Jin Song, Ayun Seol, Tae Ryeol Kim, Kyeong Seon Min, Eun Seo Park, Gi Ho Park, Hyun Gu Kang, Yeon Shik Choi and Dae Youn Hwang
    Citation: Laboratory Animal Research 2023 39:23
  34. The clinical use of sildenafil citrate (Viagra), a drug used to treat erectile dysfunction, is limited because of its many side effects on tissues. In this context, we aimed to investigate the protective effec...

    Authors: Ibrahim M. Ibrahim Laila, Samar HassabAllah Kassem and Marwa Salah ElDin Mohamed Diab
    Citation: Laboratory Animal Research 2023 39:22
  35. Globally, medicinal plants are used to treat diseases like diabetes. The present study evaluates the possible antioxidant, acute oral toxicity, the in-vitro and in-vivo antidiabetic potential of the hydro-ethanol...

    Authors: Alokali Kiba, Dipankar Saha and Bhrigu Kumar Das
    Citation: Laboratory Animal Research 2023 39:21
  36. Attention deficit hyperactivity disorder (ADHD) is one of the most prevalent neuropsychiatric disorders with morphological brain abnormalities. There is a growing body of evidence that abnormalities in the dop...

    Authors: Aysegul Gungor Aydin and Esat Adiguzel
    Citation: Laboratory Animal Research 2023 39:20
  37. Transient receptor potential canonical (TRPC) channels are non-selective cationic channels with permeability to Ca2+ and Na+. Despite their importance, there are currently few studies on TRPC in the periodontal l...

    Authors: Aeryun Kim, Ae Ri Kim, Yeong-Eui Jeon, Yun‑Jung Yoo, Yu-Mi Yang and Eun‑Jung Bak
    Citation: Laboratory Animal Research 2023 39:19
  38. The symbiosis between the Hawaiian bobtail squid Euprymna scolopes and bacterium Vibrio fischeri serves as a model for investigating the molecular mechanisms that promote the initial formation of animal-bacterial...

    Authors: Andrew G. Cecere, Rachel A. Cook and Tim I. Miyashiro
    Citation: Laboratory Animal Research 2023 39:17
  39. Liver fibrosis is an early stage of liver cirrhosis. As a reversible lesion before cirrhosis, liver failure, and liver cancer, it has been a target for drug discovery. Many antifibrotic candidates have shown p...

    Authors: Ji-Hee Hwang, Minyoung Lim, Gyeongjin Han, Heejin Park, Yong-Bum Kim, Jinseok Park, Sang-Yeop Jun, Jaeku Lee and Jae-Woo Cho
    Citation: Laboratory Animal Research 2023 39:16
  40. Datura metel (DM) stramonium is a medicinal plant often abused by Nigerians due to its psychostimulatory properties. Hallucinations, confusion, agitation, aggressiveness, anxiety, and restlessness are reported am...

    Authors: Vincent Onoriode Igben, Wilson Josiah Iju, Omogbiya Adrian Itivere, John Chukwuma Oyem, Peter Sunday Akpulu and Efe Endurance Ahama
    Citation: Laboratory Animal Research 2023 39:15
  41. Animal models are essential to understand the physiopathology of human diseases but also to evaluate new therapies. However, for several diseases there is no appropriate animal model, which complicates the dev...

    Authors: Emmanuelle Totain, Loïc Lindner, Nicolas Martin, Yolande Misseri, Alexandra Iché, Marie-Christine Birling, Tania Sorg, Yann Herault, Alain Bousquet-Melou, Pascale Bouillé, Christine Duthoit, Guillaume Pavlovic and Severine Boullier
    Citation: Laboratory Animal Research 2023 39:14
  42. Preclinical ischemic stroke studies extensively utilize the intraluminal suture method of middle cerebral artery occlusion (MCAo). General anesthesia administration is an essential step for MCAo, but anestheti...

    Authors: Jinyoung Won, Zeeshan Ahmad Khan and Yonggeun Hong
    Citation: Laboratory Animal Research 2023 39:11

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  • Laboratory Animal Research is the official journal of the Korean Association for Laboratory Animal Science. KALAS was established in 1985 in order to discuss the knowledge of the experiment, and promote the science and technology in laboratory animal sciences.

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