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  1. Animal models of constipation induced with drugs and diet have been widely employed to investigate therapeutic effects and the action mechanism of drugs against this disease. ICR mice were selected to produce ...

    Authors: Ji Eun Kim, Woo Bin Yun, Ji Eun Sung, Hyun Ah Lee, Jun Young Choi, Yeon Shik Choi, Young Suk Jung, Kil Soo Kim and Dae Youn Hwang
    Citation: Laboratory Animal Research 2016 32:3204231
  2. We investigated the effects of the sirtuin-2 (SIRT2) inhibitor AK-7 on novel object memory, cell proliferation, and neuroblast differentiation in the dentate gyrus. In addition, we also observed the relationsh...

    Authors: Hyo Young Jung, Dae Young Yoo, Jong Whi Kim, Dae Won Kim, Jung Hoon Choi, Jin Young Chung, Moo-Ho Won, Yeo Sung Yoon and In Koo Hwang
    Citation: Laboratory Animal Research 2016 32:3204224
  3. This study was performed to investigate the antioxidant and hepatoprotective effects of fermented red ginseng (Panax ginseng C.A. Meyer; FRG) on high-fat diet-induced hyperlipidemia in rats. Sprague-Dawley rats w...

    Authors: Myeong-Hwan Kim, Eun-Jin Lee, Jeong-Mu Cheon, Ki-Jun Nam, Tae-Ho Oh and Kil-Soo Kim
    Citation: Laboratory Animal Research 2016 32:3204217
  4. The purpose of this study was to delineate the various factors that affect the growth characteristics of human cancer xenografts in nude mice and to reveal the relationship between the growth characteristics a...

    Authors: Ji Young Lee, Mi-Sook Kim, Eun Ho Kim, Namhyun Chung and Youn Kyoung Jeong
    Citation: Laboratory Animal Research 2016 32:3204187
  5. Anti-atherosclerosis effects of perilla oil were investigated, in comparison with lovastatin, in rabbits fed a high-cholesterol diet (HCD). Hypercholesterolemia was induced in rabbits by feeding the HCD contai...

    Authors: Yeseul Cha, Ja Young Jang, Young-Hwan Ban, Haiyu Guo, Kyungha Shin, Tae-Su Kim, Sung-Pyo Lee, Jieun Choi, Eun-Suk An, Da-Woom Seo, Jung-Min Yon, Ehn-Kyoung Choi and Yun-Bae Kim
    Citation: Laboratory Animal Research 2016 32:3203179
  6. Pet turtles are known as a source of Salmonella infection to humans when handled in captivity. Thirty four turtles purchased from pet shops and online markets in Korea were examined to determine whether the turtl...

    Authors: Du-San Back, Gee-Wook Shin, Mitchell Wendt and Gang-Joon Heo
    Citation: Laboratory Animal Research 2016 32:3203166
  7. The approach and novelty of this scientific work was to formulate the appropriate Streptozotocin (STZ) and Alloxan dosage in different routes of administration to imply minimum mortality rate and high incidenc...

    Authors: Ataroalsadat Mostafavinia, Abdodlah Amini, Seyed Kamran Ghorishi, Ramin Pouriran and Mohammad Bayat
    Citation: Laboratory Animal Research 2016 32:3203160
  8. Inflammatory bowel disease is a chronic inflammatory disorder occurring in the gastrointestinal track. However, the efficacy of current therapeutic strategies has been limited and accompanied by side effects. ...

    Authors: Seungho Choi, Jong-Kyu Woo, Yeong-Su Jang, Ju-Hee Kang, Jung-Eun Jang, Tae-Hoo Yi, Sang-Yong Park, Sun-Yeou Kim, Yeo-Sung Yoon and Seung Hyun Oh
    Citation: Laboratory Animal Research 2016 32:3203151
  9. Dendrobium moniliforme (L.) Sw., an herb of the Orchidaceae family, has long been used in traditional medicine to strengthen bones, nourish the stomach, and promote the production of bodily fluid. Recently, polys...

    Authors: Mu-Jin Lee, Ho-Kyung Jung, Min-Suk Kim, Ji-Hun Jang, Mi-Ok Sim, Tea-Mook Kim, Ho Park, Byung-Kwan Ahn, Hyun-Woo Cho, Jung-Hee Cho, Won-Seok Jung and Jong-Choon Kim
    Citation: Laboratory Animal Research 2016 32:3203144
  10. The aim of this study was to examine the therapeutic potential of sulfasalazine and prednisolone in a mouse collagen antibody-induced arthritis (CAIA) model. Twenty-five male BALB/c mice were randomly divided ...

    Authors: Joo Hye Sim, Won Kil Lee, Yun Seok Lee and Jin Seok Kang
    Citation: Laboratory Animal Research 2016 32:3203135
  11. We designed 4 primers for amplification of allelespecific PCR products from leptin receptor mutant and normal alleles using primer design web service for tetraprimer ARMS-PCR (Figure 1) i.e., Lepr-forward oute...

    Authors: Harry Jung, Hajin Nam and Jun-Gyo Suh
    Citation: Laboratory Animal Research 2016 32:3202133

    The original article was published in Laboratory Animal Research 2016 32:Art9

  12. Descending of the testes is an important process for spermatogenesis and cryptorchidism is one of the most relevant genital defects in dogs. In a previous study, we observed abnormal morphology and proliferati...

    Authors: Hyo Young Jung, Dae Young Yoo, Young Kwang Jo, Geon A. Kim, Jin Young Chung, Jung Hoon Choi, Goo Jang and In Koo Hwang
    Citation: Laboratory Animal Research 2016 32:3202128
  13. Whereas increasing concerns about radiation exposure to nuclear disasters or side effects of anticancer radiotherapy, relatively little research for radiation damages or remedy has been done. The purpose of th...

    Authors: Seung-Hyun Ryu, Jong-Hyung Park, Eui-Suk Jeong, Soo-Young Choi, Seung-Hoon Ham, Jin-Il Park, Hee-Yeon Jeon, Jun-Young Kim, Ran-Ji Yoo, Yong-Jin Lee, Sang-Keun Woo and Yang-Kyu Choi
    Citation: Laboratory Animal Research 2016 32:3202116
  14. To investigate the beneficial effects of diosgenin (DC) on the multiple types of brain damage induced by Aβ-42 peptides and neurotoxicants, alterations in the specific aspects of brain functions were measured ...

    Authors: Eun-Kyoung Koh, Woo-Bin Yun, Ji-Eun Kim, Sung-Hwa Song, Ji-Eun Sung, Hyun-Ah Lee, Eun-Ji Seo, Seung-Wan Jee, Chang-Joon Bae and Dae-Youn Hwang
    Citation: Laboratory Animal Research 2016 32:3202105
  15. Helicobacter pylori colonizes the gastric mucosa of about half of the world’s population, causing chronic gastritis and gastric cancer. An increasing emergence of antibiotic-resistant H. pylori arouses demand on ...

    Authors: Dong-Jae Kim, Min-Jung Kang, Jin-A Choi, Dae-Seung Na, Jin-Beom Kim, Chun-Soo Na and Jong-Hwan Park
    Citation: Laboratory Animal Research 2016 32:3202099
  16. The aim of this study is to investigate the potential of anti-osteoarthritis effects on egg white-chalcanthite (EC), purple bamboo salts (PBS), and a mixture of EC and PBS (EC+PBS). EC is a mixture of egg whit...

    Authors: Tae-Hee Lee, Hyun-kyung Song, Ja-Young Jang, Dong-Yoon Kim, Hyun-Kyung Park, Eun-A Choi and Beom-Seok Han
    Citation: Laboratory Animal Research 2016 32:3202091
  17. The antibacterial activities of the essential oil of Eucalyptus globulus (EOEG) was determined against 7 fish pathogenic bacteria (Edwardsiella tarda, Streptococcus iniae, S. parauberis, Lactococcus garviae, Vibr...

    Authors: Joon-Woo Park, Mitchell Wendt and Gang-Joon Heo
    Citation: Laboratory Animal Research 2016 32:3202087
  18. Nonhuman primates are increasingly used in biomedical research since they are highly homologous to humans compared to other rodent animals. However, there is limited reliable reference data of the clinical pat...

    Authors: Hyun-Kyu Park, Jae-Woo Cho, Byoung-Seok Lee, Heejin Park, Ji-Seok Han, Mi-Jin Yang, Wan-Jung Im, Do-Yong Park, Woo-Jin Kim, Su-Cheol Han and Yong-Bum Kim
    Citation: Laboratory Animal Research 2016 32:3202079
  19. A 19-month-old male German shepherd dog was presented with a hindlimb footpad mass. The mass was excised and histopathology was performed. Grossly, the cut section of the mass had multiple wellcircumscribed no...

    Authors: Eun-Mi Lee, Ah-Young Kim, Eun-Joo Lee and Kyu-Shik Jeong
    Citation: Laboratory Animal Research 2016 32:10
  20. The C57BLKS/J-Leprdb mouse has a point mutation in the leptin receptor gene and is one of the most useful animal model for non-insulin dependent diabetes mellitus in human. Since the homozygote of C57BLKS/J-Leprd...

    Authors: Harry Jung, Hajin Nam and Jun-Gyo Suh
    Citation: Laboratory Animal Research 2016 32:9
  21. Animal models for gastric ulcers produced by physical, pharmacological and surgical methods have been widely employed to evaluate therapeutic drugs and investigate the mechanism of action of this disease. ICR ...

    Authors: Sung Hwa Song, Ji Eun Kim, Jun Go, Eun Kyoung Koh, Ji Eun Sung, Hyun Ah Lee, Kyung Min Choi, Hae Deun Kim, Young Suk Jung, Kil Soo Kim and Dae Youn Hwang
    Citation: Laboratory Animal Research 2016 32:7
  22. Cynomolgus monkeys as nonhuman primates are valuable animal models because they have a high level of human gene homology. There are many reference values for hematology and biochemistry of Cynomolgus monkeys t...

    Authors: Kangmoo Choi, Jaejin Chang, Min-Jae Lee, Seungsu Wang, Kimhong In, Wilhelm C. Galano-tan, Sanghun Jun, Kahee Cho, Yong-Hwa Hwang, Sung-Ju Kim and Wanje Park
    Citation: Laboratory Animal Research 2016 32:6
  23. Asparagus cochinchinensis has been used to treat various diseases including fever, cough, kidney disease, breast cancer, inflammatory disease and brain disease, while IL-4 cytokine has been considered as key regu...

    Authors: Ji-Eun Sung, Hyun-Ah Lee, Ji-Eun Kim, Jun Go, Eun-Ji Seo, Woo-Bin Yun, Dong-Seob Kim, Hong-Joo Son, Chung-Yeoul Lee, Hee-Seob Lee and Dae-Youn Hwang
    Citation: Laboratory Animal Research 2016 32:5
  24. In this study, the potential hepatotoxicity of 1,3-dichloro-2-propanol and its hepatotoxic mechanisms in rats was investigated. The test chemical was administered orally to male rats at 0, 27.5, 55, and 110 mg...

    Authors: In-Chul Lee, Sang-Min Lee, Je-Won Ko, Sung-Hyeuk Park, In-Sik Shin, Changjong Moon, Sung-Ho Kim and Jong-Choon Kim
    Citation: Laboratory Animal Research 2016 32:4
  25. A dysfunction of endoplasmic reticulum (ER) stress response can result in various diseases, including cancer, inflammation, diabetes and neurodegenerative disorders. To investigate whether ER stress response c...

    Authors: Ji-Eun Kim, Jun Go, Ji-Eun Sung, Hyun-Ah Lee, Eun-Ji Seo, Woo-Bin Yun and Dae-Youn Hwang
    Citation: Laboratory Animal Research 2016 32:3
  26. The purpose of this study was to evaluate the effects of thiopental versus propofol on cardiopulmonary functions, when used as an induction agent prior to isoflurane anesthesia in rhesus monkeys. Eight healthy...

    Authors: Yun-Jung Choi, Hye-Jin Park, Hyeon-Ho Kim, Yun-Jin Lee, Kyeong-Cheon Jung, Seong-Hoe Park and Jae-Il Lee
    Citation: Laboratory Animal Research 2016 32:2
  27. In this study, we observed the ontogenetic changes in glucose transporter 3 (GLUT3) immunoreactivity, a major neuronal GLUT, in the dentate gyrus of mouse brains at various ages: postnatal day (P) 1, 7, 14, 28...

    Authors: Hyo Young Jung, Hee Sun Yim, Dae Young Yoo, Jong Whi Kim, Jin Young Chung, Je Kyung Seong, Yeo Sung Yoon, Dae Won Kim and In Koo Hwang
    Citation: Laboratory Animal Research 2016 32:1
  28. As the request of the authors, the following information has been changed.

    Authors: Jangbeen Kyung, Dajeong Kim, Dongsun Park, Yun-Hui Yang, Ehn-Kyoung Choi, Sung-Pyo Lee, Tae-Su Kim, Yoon-Bok Lee and Yun-Bae Kim
    Citation: Laboratory Animal Research 2015 31:3103153

    The original article that this is related to.

  29. In order to assess inhibitory potentials of white rose petal extracts (WRPE) on the activities of enzymes related to dermal aging according to the extraction conditions, three extraction methods were adopted. ...

    Authors: Ehn-Kyoung Choi, Haiyu Guo, Jae-Kwon Choi, Su-Kil Jang, Kyungha Shin, Ye-Seul Cha, Youngjin Choi, Da-Woom Seo, Yoon-Bok Lee, Seong-Soo Joo and Yun-Bae Kim
    Citation: Laboratory Animal Research 2015 31:3103148
  30. The aim of this study was to verify subacute oral dose toxicity of positively charged 100 nm zinc oxide (ZnOAE100[+]) nanoparticles (NPs) in Sprague-Dawley rats. ZnOAE100[+] NPs were administered to rats of each ...

    Authors: Je-Won Ko, Eun-Taek Hong, In-Chul Lee, Sung-Hyeuk Park, Jong-Il Park, Nak-Won Seong, Jeong-Sup Hong, Hyo-In Yun and Jong-Choon Kim
    Citation: Laboratory Animal Research 2015 31:3103139
  31. Curcumin provides various biological effects through its anti-inflammatory and antioxidant properties. Moreover, curcumin exerts a neuroprotective effect against ischemic condition-induced brain damage. Protei...

    Authors: Fawad-Ali Shah, Dong-Ju Park, Sang-Ah Gim and Phil-Ok Koh
    Citation: Laboratory Animal Research 2015 31:3103134
  32. Some polymers and bioactive compounds derived from Styela clava tunic (SCT) have been reported as traditional medicine for the treatment of inflammation, oxidative stress and surgical wounds although there is lit...

    Authors: Eun-Kyoung Koh, Ji-Eun Sung, Ji-Eun Kim, Jun Go, Sung-Hwa Song, Hyun-Ah Lee, Hong-Joo Son, Young-Jin Jung, Yong Lim and Dae-Youn Hwang
    Citation: Laboratory Animal Research 2015 31:3103125
  33. This study was conducted to investigate the effects of lutein alone or in combination with vitamin C on the antioxidant defense system in rats. A total of 18 eight-week-old male Sprague Dawley (SD) rats were r...

    Authors: Min-Hae Song, Eu-Chul Shin, Dae-Youn Hwang and In-Surk Jang
    Citation: Laboratory Animal Research 2015 31:3103117
  34. The effect of pentoxifylline (PTX) administration on histomorphological parameters of streptozotocin (STZ)-induced type 1 diabetes mellitus (DM) in male rat testes were evaluated. We randomly divided 40 male r...

    Authors: Abbas Piryaei, Azam Najar and Mohammad Bayat
    Citation: Laboratory Animal Research 2015 31:3103111
  35. To evaluate the hepatotoxicity and nephrotoxicity of Galla Rhois (GR) toward the liver and kidney of ICR mice, alterations in related markers including body weight, organ weight, urine composition, liver patho...

    Authors: Jun Go, Ji-Eun Kim, Eun-Kyoung Koh, Sung-Hwa Song, Ji-Eun Seung, Chan-Kyu Park, Hyun-Ah Lee, Hong-Sung Kim, Jae-Ho Lee, Beum-Soo An, Seung-Yun Yang, Yong Lim and Dae-Youn Hwang
    Citation: Laboratory Animal Research 2015 31:3103101
  36. As the request of the authors, the following information has been changed.

    Authors: Jingmei Cai, Tae-Su Kim, Ja Young Jang, Jihyun Kim, Kyungha Shin, Sung-Pyo Lee, Ehn-Kyoung Choi, Sa-Hyun Kim, Min Park, Jong Bae Kim and Yun-Bae Kim
    Citation: Laboratory Animal Research 2015 31:3102099

    The original article that this is related to.

  37. We developed pancreatic and duodenal homeobox1 (Pdx1) knockout mice to improve a compensatory hyperinsulinemia, which was induced by hyperplasia in the β cells or Langerhans’ islands, as the diabetic model mice. ...

    Authors: Haruo Hashimoto, Tsutomu Kamisako, Takahiro Kagawa, Seiki Haraguchi, Mika Yagoto, Ri-ichi Takahashi, Kenji Kawai and Hiroshi Suemizu
    Citation: Laboratory Animal Research 2015 31:3102093
  38. A number of Helicobacter species may confound experimental data because of their association with disease progressing in various kinds of laboratory animals. Screening of Helicobacter species is particularly desi...

    Authors: Sunhwa Hong, Yungho Chung, Won-Guk Kang, Yeon-Shik Choi and Okjin Kim
    Citation: Laboratory Animal Research 2015 31:3102086
  39. Streptococcus pneumoniae is a major human pathogen that is involved in community-acquired pneumonia. Tumor necrosis factor-alpha (TNF-α) is a pro-inflammatory cytokine that activates immune responses against infe...

    Authors: Dong-Gu Jeong, Jin-Hee Seo, Seung-Ho Heo, Yang-Kyu Choi and Eui-Suk Jeong
    Citation: Laboratory Animal Research 2015 31:3102078
  40. Eosinophilic, polymorphic and pruritic eruption associated with radiotherapy (EPPER) can occur in cancer patients after irradiation. In this study, we characterized the clinical and histopathological features ...

    Authors: Joong Sun Kim, Won Seok Jang, Min Ji Bae, Sunhoo Park and Seung Sook Lee
    Citation: Laboratory Animal Research 2015 31:7
  41. Curcumin exerts a protective effect in cerebral ischemia through its anti-oxidant and anti-inflammatory activities. γ-enolase is a glycolytic enzyme expressed in neurons that is known to exerts a neuroprotecti...

    Authors: Sang-Ah Gim, So-Ra Lee, Fawad-Ali Shah and Phil-Ok Koh
    Citation: Laboratory Animal Research 2015 31:6
  42. Inflammation has recently been implicated in cancer formation and progression. As tissue transglutaminase (TG2) has been associated with both inflammatory signaling and tumor cell behavior, we propose that TG2...

    Authors: Keunhee Oh, Hyeong-Gon Moon, Dong-Sup Lee and Young-Bok Yoo
    Citation: Laboratory Animal Research 2015 31:5
  43. The aim of this study is to assess the effects of different glucocorticoid administration protocols on biomechanical properties of the first lumbar vertebral body in rats. We divided 40 male rats into the foll...

    Authors: Azam Najar, Mohammadjavad Fridoni, Fatemesadat Rezaei, Saba Bayat and Mohammad Bayat
    Citation: Laboratory Animal Research 2015 31:4
  44. Procedures involving complex surgical techniques in rats, such as placement of abdominal aortic graft require extended duration of surgical anesthesia, which often can be achieved by repeated administrations o...

    Authors: Arun H. S. Kumar and Anthony J. P. Clover
    Citation: Laboratory Animal Research 2015 31:3
  45. Genetic background in animal models is an intrinsic research variable in biomedical research. Although inbred strains offer genetic uniformity, the outbred stocks, known for genetic variability are often used ...

    Authors: Marcia Brower, Martha Grace, Catherine M. Kotz and Vijay Koya
    Citation: Laboratory Animal Research 2015 31:2
  46. The common marmoset (Callithrix jacchus) is a small-bodied, popular New World monkey and is used widely in reproductive biology, neuroscience, and drug development, due to its comparative ease of handling, high r...

    Authors: Jun-Won Yun, Jae-Bum Ahn and Byeong-Cheol Kang
    Citation: Laboratory Animal Research 2015 31:1

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  • Laboratory Animal Research is the official journal of the Korean Association for Laboratory Animal Science. KALAS was established in 1985 in order to discuss the knowledge of the experiment, and promote the science and technology in laboratory animal sciences.

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